热毒宁注射液联合利奈唑胺治疗呼吸机相关性肺炎疗效及对血清PCT、IL-6和CRP水平的影响  

Efficacy of Redonin Injection Combined with Linezolid in Treatment of Ventilator Associated Pneumonia and Its Effect on Serum Levels of PCT, IL-6 and CRP

作　　者：刘跃辉[1] 郝东宁[1] 马肃[1] 周峰[1] 王永[1] 王泽林 LIU Yuehui;HAO Dongning;MA Su;ZHOU Feng;WANG Yong;WANG Zelin(Department of Critical Care Medicine,The First Hospital of Yulin,Yulin 718000,Shaanxi,China)

机构地区：[1]榆林市第一医院重症医学科,陕西榆林718000

出　　处：《中华中医药学刊》2020年第12期209-212,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：陕西省科技计划(2016LL07-2-03-17)。

摘　　要：目的探讨热毒宁注射液联合利奈唑胺治疗呼吸机相关性肺炎的疗效及对血清PCT、IL-6和CRP水平影响。方法选取来医院接受治疗的126例呼吸机相关性肺炎患者,随机分为两组各63例。对照组患者给予静脉滴注利奈唑胺,实验组在对照组基础上静脉滴注热毒宁注射液,两组患者均持续治疗10 d。对比两组患者的临床疗效、临床症状消失时间、中医症候积分、APACHE评分和CPIS评分、肺功能指标水平、血气指标及PCT、IL-6和hs-CRP水平变化。结果治疗后,实验组总有效率较高(P<0.05);实验组患者罗音消失时间、住院时间及临床症状消失时间显著低于对照组(P<0.05);两组患者治疗前中医症候积分差异无统计学意义(P>0.05);两组患者治疗后咳嗽、发热、痰壅、气喘、肺部体征评分显著降低(P<0.05);并且实验组降低较多(P<0.05);两组患者治疗前APACHE评分和CPIS评分差异无统计学意义(P>0.05);两组患者治疗后APACHE评分和CPIS评分明显降低(P<0.05);并且实验组降低较多(P<0.05);两组患者治疗前FEV1、PEF和FEV1/FVC水平差异无统计学意义(P>0.05);两组患者FEV1、PEF和FEV1/FVC水平显著升高(P<0.05);并且治疗组升高较多(P<0.05)。两组患者治疗前PaCO2、PaO2水平无差异(P>0.05);两组患者PaCO2水平显著降低,PaO2水平显著升高(P<0.05);并且治疗组改善程度较大(P<0.05);两组患者治疗前PCT、IL-6和CRP水平差异无统计学意义(P>0.05);两组患者治疗后PCT、IL-6和CRP水平明显降低(P<0.05);并且实验组PCT、IL-6和CRP水平低于对照组(P<0.05)。结论采用热毒宁注射液联合利奈唑胺治疗呼吸机相关性肺炎具有较好的治疗效果。Objective To investigate the efficacy of Redonin Injection combined with linezolid in the treatment of ventilator associated pneumonia and its effect on serum levels of PCT, IL-6 and CRP. Methods A total of 126 patients with ventilator-associated pneumonia were randomly divided into two groups, 63 cases in each. Patients in the control group were given intravenous infusion of linezolid, while those in the experimental group were given intravenous infusion of Redonin Injection on the basis of the control group. Patients in both groups were continuously treated for 10 days. The clinical efficacy, clinical symptom disappearance time, TCM syndrome score, APACHE score and CPIS score, lung function index level, blood gas index and levels of PCT, IL-6 and hs-CRP of the two groups were compared. Results After treatment, the total effective rate of the experimental group was higher(P<0.05). The rale disappearance time, hospitalization time and clinical symptom disappearance time of the experimental group were significantly shorter than those of the control group(P<0.05). There was no difference in TCM syndrome score between the two groups before treatment(P>0.05). After treatment, scores of cough, fever, phlegm obstruction, asthma and pulmonary signs were significantly decreased in the two groups(P<0.05). And the experimental group’s decreased significantly(P<0.05). There was no difference in APACHE score or CPIS score between the two groups before treatment(P>0.05). After treatment, APACHE score and CPIS score were significantly decreased in the two groups(P<0.05). And the experimental group’s decreased significantly(P<0.05). There was no difference in FEV1, PEF or FEV1/FVC between the two groups before treatment(P>0.05). Levels of FEV1, PEF and FEV1/FVC were significantly increased in the two groups(P<0.05). And the treatment group’s increased more obviously(P<0.05). There was no difference in levels of PaCO2 or PaO2 between the two groups before treatment(P>0.05). The PaCO2 level in the two groups was significant

关 键 词：热毒宁注射液 利奈唑胺 呼吸机相关性肺炎 血清PCT、IL-6和CRP水平 

分 类 号：R259.631[医药卫生—中西医结合]