Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application  

作　　者：Yuqing Zhang Danni Sun Jun Cheng James Kit Hon Tsoi Jiang Chen 

机构地区：[1]School and Hospital of Stomatology,Fujian Medical University,Fuzhou 350002,Fujian,China [2]Stomatological Key Laboratory of Fujian College and University,Fujian Medical University,Fuzhou 350002,Fujian,China [3]Faculty of Dentistry,Dental Materials Science,Division of Applied Oral Sciences and Community Dental Care,The University of Hong Kong,Hong Kong SAR,China [4]Shaanxi Key Laboratory of Biomedical Metal Materials,Northwest Institute for Non-ferrous Metal Research,Xi’an 710016,Shaanxi,China

出　　处：《Regenerative Biomaterials》2020年第1期119-127,共9页再生生物材料（英文版）

基　　金：The study was partially supported by the National Natural Science Foundation of China(NSFC)(grant number 81771126).

摘　　要：Binary titanium–niobium(Ti–Nb)alloys have recently been attracted due to low Young’s moduli and non-toxic properties.This study explores the influence of low Nb content(0–25 wt%)on the comprehensive parameters of tensile stress–strain relationships(ultimate strength(rUTS),yield strength(r0.2)and elastic modulus(E)),surfaces properties(Vickers microhardness,surface roughness(Ra),water contact angle(WCA),X-ray diffraction(XRD)and scanning electron microscopy(SEM)),corrosion resistance(in artificial saliva and lactic acid)and biological properties(cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts)of Ti–xNb alloys(x紏5,10,15,20 and 25 wt%),with using commercially pure grade 2 titanium(cp-Ti)as control.XRD results shown that all the Ti–xNb alloys comprised atb Ti alloy phases,such that the b phase increased correspondingly with the increased amount of Nb in the alloy,as well as the reduction of E(69–87 GPa).Except Ti–5Nb,all other Ti–xNb alloys showed a significantly higher hardness,increased rUTS and r0.2,and decreased WCA compared with cp-Ti.No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions.The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour,but the proliferation rate of the Ti–5Nb alloy was lower than other groups.In overall,binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance,while Ti–5Nb should be used with caution.

关 键 词：biomaterial titanium-niobium binary titanium alloys low Young’s modulus BIOCOMPATIBILITY 

分 类 号：TG146[一般工业技术—材料科学与工程]