Efficacy of concentrated growth factors combined with mineralized collagen on quality of life and bone reconstruction of guided bone regeneration  

作　　者：Yan Dai Xiao-Hui Han Li-Hua Hu Hai-Wei Wu Sheng-Yun Huang Yu-Peng Lu 

机构地区：[1]Department of Oral and Maxillofacial Surgery,Central Hospital of Zibo,Shandong University,Zibo 255036,China [2]Department of Oral and Maxillofacial Surgery [3]Department of Prosthodontics,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China [4]Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials,Ministry of Education,Shandong University,Jinan 250061,China [5]School of Materials Science and Engineering,Shandong University,Jinan 250061,China

出　　处：《Regenerative Biomaterials》2020年第3期313-320,共8页再生生物材料（英文版）

基　　金：funded by China Postdoctoral Science Foundation Grant(No.2019M652380).

摘　　要：To evaluate the clinical efficacy of concentrated growth factors(CGFs)combined with mineralized collagen(MC)in guided bone regeneration(GBR).A retrospective study involving 29 patients treated with GBR technique,which was performed either CGF and MC complexes or MC alone.Implants were inserted simultaneously and cone-beam computed tomography was taken immediately,at 3 and 6 months postoperation.Questionnaires were completed by all patients so as to evaluate the main symptoms and daily activities during the first week after surgery.The outcomes of the two groups were statistically compared.All implants healed uneventfully.Patients in both groups suffered from different levels of discomfort for the reason of swelling,pain and chewing impairment on 1-2 days.Meanwhile,swelling of the Trial group was weaker than the Control group.When compared with the Control group,pain levels in Trial group were more rapidly reduced and patients took fewer analgesics from Day 3.Furthermore,the reconstitution mean value of the graft was thicker at 3 and 6 months in Trial group.CGFs complex with MC were beneficial to relieve the clinical symptoms,promote the peri-implant bone regeneration and shorten the healing time.

关 键 词：concentrated growth factors mineralized collagen guided bone regeneration bone augmentation OSSEOINTEGRATION 

分 类 号：R318[医药卫生—生物医学工程]