Synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N‑heteroarenes with 4-glycosyl-dihydropyridines  

作　　者：Qingbing Wang Juan Duan Pingping Tang Gong Chen Gang He 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Science China Chemistry》2020年第11期1613-1618,共6页中国科学（化学英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(21672105,21725204,91753124);Natural Science Foundation of Tianjin(17JCYBJC19700,18JCZDJC32800);the Fundamental Research Funds for the Central Universities(Nankai University)(63191746).

摘　　要：A radical-mediated method was reported for diastereoselective synthesis of non-classical heteroaryl C-glycosides via Minisci-type alkylation of N-heteroarenes with 4-glycosyl-1,4-dihydropyridine(DHP)reagents.These DHP reagents serve as convenient precursors for various glycosyl radicals under the activation of single electron transfer(SET)oxidation by persulfate and visible light irradiation with or without photocatalyst.

关 键 词：non-classical C-glycoside Minisci reaction 4-gIycosyl-dihydropyridine 

分 类 号：TQ460.1[化学工程—制药化工]