外周血结核杆菌感染T细胞斑点试验对骨关节结核的诊断准确性研究:一项病例对照研究  

T-cell spot of tuberculosis assay in diagnosis of osteoarticular tuberculosis

作　　者：李晓亮[1] 杨志刚[1] 王俊丽 宋琼珠 陈卓昌[1] LI Xiao-liang;YANG Zhi-gang;WANG Jun-li;SONG Qiong-zhu;CHEN Zhuo-chang(Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院呼吸与危重症科,郑州450003

出　　处：《医药论坛杂志》2020年第12期75-78,共4页Journal of Medical Forum

摘　　要：目的本文旨在探讨外周血结核杆菌感染T细胞斑点试验(T-SPOT.TB)对骨关节结核的诊断准确性。方法回顾性收集2015年1月1日至2019年12月31日在中国河南省人民医院呼吸与危重症科住院的疑似骨关节结核患者231例,所有患者均行外周血结核杆菌感染T细胞斑点试验检查。以骨关节结核诊断的综合标准为金标准,确诊骨关节结核患者77例,非骨关节结核患者113例。分析外周血结核杆菌感染T细胞斑点试验诊断骨关节结核的灵敏度、特异度、阳性预测值、阴性预测值、阳性似阳比、阴性似然比、准确度。结果外周血T-SPOT.TB诊断骨关节结核的敏感度、特异度、准确度分别为0.75、0.71、0.73。结论外周血结核杆菌感染T细胞斑点试验对诊断骨关节结核有较好的诊断价值。Objective To evaluate the T-cell spot of tuberculosis(T-SPOT.TB)assay in the diagnosis of osteoarticular tuberculosis(OTB).Methods From January 2015 to December 2019,a total of 231 suspected patients with OTB accepted T-SPOT.TB assay.According to composite reference standard(CRS)as gold standard,which included clinical,laboratory,histopathological,radiological and≥2 months follow-up data,77 patients were diagnosed with OTB,the other 113 patients were diagnosed with non-OTB.The sensitivity,specificity,positive predict value,negative predict value and accuracy of the T-SPOT.TB was evaluated.Results The sensitivity,specificity and accuracy of T-SPOT.TB assay was 0.75,0.71,0.73.Conclusion This retrospective case-control study demonstrated that T-SPOT.TB assay is a relatively useful tool for rapid diagnosis of osteoarticular TB.

关 键 词：骨关节结核外周血结核杆菌感染T 细胞斑点试验诊断准确性研究 

分 类 号：R529.2[医药卫生—内科学]