孟鲁司特联合维生素D制剂对支气管哮喘患儿肺功能、氧化-抗氧化失衡和生活质量的影响  

Effects of Montelukast Combined with Vitamin D Preparations on Pulmonary Function,Oxidation-Antioxidant Imbalance and Quality of Life in Children with Bronchial Asthma

作　　者：章成伟 林瑾 Zhang Chengwei;Lin Jin(Maternal and Child Health Care Hospital of Lishui)

机构地区：[1]丽水市妇幼保健院,浙江丽水323000

出　　处：《儿科药学杂志》2021年第1期30-35,共6页Journal of Pediatric Pharmacy

摘　　要：目的:观察孟鲁司特联合维生素D制剂对支气管哮喘患儿肺功能、氧化-抗氧化失衡和生活质量的影响。方法:将95例支气管哮喘患儿按照随机数表法分为观察组48例和对照组47例。对照组在常规治疗基础上给予孟鲁司特钠咀嚼片治疗,观察组在对照组治疗基础上加用维生素D制剂治疗,两组均治疗8周。记录两组患儿血清维生素D水平、儿童哮喘控制测试(CACT)评分、肺功能、氧化应激指标的变化,并比较两组患儿生活质量改善情况。结果:治疗后观察组血清25-(OH)D水平为(30.87±6.49)ng/m L,较治疗前的(23.93±7.34)ng/m L增高(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05),治疗后观察组血清25-(OH)D水平高于对照组的(24.20±7.91)ng/m L(P<0.05)。两组治疗后C-ACT分级和平均分值均较治疗前显著增高(P<0.05),观察组治疗后C-ACT分级和平均分值均高于对照组(P<0.05);两组治疗后FEV1、FEV1/FVC、PEF、PEFR均较治疗前提高(P<0.05);观察组治疗后以上指标均高于对照组(P<0.05);两组治疗后血清SOD、GSH-Px水平较治疗前升高,MAD水平较治疗前降低(P均<0.05);观察组治疗后SOD、GSH-Px高于对照组,MAD低于对照组(P均<0.05);两组治疗后中文版儿童生命质量哮喘特异性量表(PedsQL)中4个维度评分和总评分均较治疗前升高(P<0.05),观察组治疗后以上评分均高于对照组(P<0.05)。观察组与对照组不良发生率比较差异无统计学意义(8.33%vs 6.38%,P>0.05)。结论:孟鲁司特联合维生素D制剂可显著提高支气管哮喘患儿机体维生素D水平,提高肺功能,促进氧化-抗氧化平衡,抑制氧化应激,有利于哮喘控制和生活质量的提高。Objective:To observe the effects of montelukast combined with vitamin D preparations on pulmonary function,oxidationantioxidant imbalance and quality of life in children with bronchial asthma.Methods:A total of 95 children with bronchial asthma were divided into the observation group(n=48 cases)and the control group(n=47 cases)according to the random number table.The control group was treated with montelukast chewable tablets on the basis of conventional treatment,and the observation group received vitamin D preparations on the basis of the control group.Both groups were treated for 8 weeks.Serum level of vitamin D,Childhood Asthma Control Test(C-ACT)score,lung function and oxidative stress of two groups were recorded,and improvement of quality of life were compared.Results:After treatment,the serum level of 25-(OH)D in the observation group was(30.87±6.49)ng/m L,higher than that before treatment(23.93±7.34)ng/m L(P<0.05),there was no statistical significance in the control group before and after treatment(P>0.05).After treatment,the serum level of 25-(OH)D in the observation group was higher than that in the control group(24.20±7.91)ng/m L(P<0.05).After treatment,the C-ACT grading and average score of two groups were higher than those before treatment(P<0.05),and the C-ACT grading and average score of the observation group after treatment were higher than those of the control group(P<0.05).After treatment,FEV1,FEV1/FVC,PEF and PEFR in both groups were all higher than those before treatment(P<0.05),the above indicators in the observation group after treatment were higher than those in the control group(P<0.05).After treatment,the serum levels of SOD and GSH-Px in both groups were significantly higher than those before treatment,and the serum levels of MAD were significantly lower than those before treatment(P<0.05).After treatment,SOD and GSH-Px of the observation group were higher than those of the control group,and MAD was lower than that of the control group(P<0.05).The four dimension scores and total score

关 键 词：孟鲁司特 维生素D 支气管哮喘 肺功能 氧化应激 

分 类 号：R725.6[医药卫生—儿科]