临床药师参与耐甲氧西林金黄色葡萄球菌骨髓炎伴肾功能亢进患儿的治疗实践  

Pharmaceutical Practice for Treatment of Methicillin Resistant Staphylococcus Aureus Osteomyelitis in Children with Augmented Renal Clearance by Clinical Pharmacists

作　　者：何翠瑶[1] 吴青[1] 吕凤俊[1] 樊继山[1] He Cuiyao;Wu Qing;Lyu Fengjun;Fan Jishan(Children’s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science and Technology Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院,儿童发育疾病研究教育部重点实验室,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆400014

出　　处：《儿科药学杂志》2021年第1期45-49,共5页Journal of Pediatric Pharmacy

摘　　要：目的:探讨临床药师在儿童耐甲氧西林金黄色葡萄球菌(MRSA)骨髓炎个体化抗感染治疗中的作用。方法:临床药师通过会诊1例万古霉素治疗儿童急性骨髓炎失败的病例,根据患者临床情况及相关检查结果,并结合国内外文献,从PK/PD角度对万古霉素治疗失败的原因进行分析,提出万古霉素治疗失败后替代治疗方案。结果:临床药师提出的治疗方案被医师采纳,患者骨关节感染得到有效控制。结论:临床药师发挥药学专长指导特殊人群使用抗菌药物,可以有效提高抗菌药物临床治疗的疗效。Objective:To probe into the role of clinical pharmacists in the individualized treatment of anti-infection for methicillin resistant Staphylococcus aureus(MRSA)osteomyelitis in children.Methods:Clinical pharmacists participated into the consultation of a case of failure in vancomycin treatment of acute osteomyelitis.Based on the patient’s clinical conditions and relevant examination results,combined with domestic and foreign literature,the causes for the failure of vancomycin treatment were analyzed from the perspective of PK/PD,and the alternative treatment regimen after vancomycin treatment failure was proposed.Results:The treatment regimen suggested by the clinical pharmacists was adopted by the clinicians,the bone and joint infection of the patient was effectively controlled.Conclusion:Clinical pharmacists give full play to the pharmaceutical expertise to guide use of antibiotics in special populations,which can effectively improve the efficacy of antibiotics in clinical treatment.

关 键 词：耐甲氧西林金黄色葡萄球菌 骨髓炎 万古霉素 临床药师 

分 类 号：R969.3[医药卫生—药理学]