白癜风患者血清白细胞介素33及其可溶性受体ST2水平检测及意义  

The serum levels and clinical significance of interleukin-33 and soluble ST2 in patients with vitiligo

作　　者：杨丽[1] 陆东庆[1] 马寒 YANG Li;LU Dong-qing;MA Han(Department of Dermatology,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China)

机构地区：[1]中山大学附属第五医院皮肤科,广东珠海519000

出　　处：《皮肤性病诊疗学杂志》2020年第6期400-404,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:探讨白癜风患者血清白细胞介素33(IL-33)及其可溶性受体ST2(sST2)表达水平的变化及其临床意义。方法:采用酶联免疫吸附试验对62例白癜风患者和30例健康对照组血清IL-33和sST2表达水平进行检测,并分析IL-33和sST2在白癜风患者不同分期、面积、病程等分组中的表达差异。结果:白癜风患者外周血中IL-33和sST2水平在进展期及稳定期均明显高于正常对照组(IL-33:t值分别为4.67、2.34,P值分别为0.004、0.031;sST2:t值分别为3.59、2.09,P值分别为0.027、0.045)。白癜风患者自身抗体异常组sST2水平明显高于无自身抗体异常组,差异有统计学意义(t=2.46,P=0.015);不同分期、性别、白斑面积、家族史、精神应激、微量元素临床亚组间IL-33和sST2水平差异均无统计学意义(P值均>0.05)。外周血IL-33和sST2水平与年龄及病程均无明显相关性(P值均>0.05)。结论:IL-33及sST2可能与白癜风的发病密切相关。IL-33水平升高可能主要发生在白癜风起始阶段,与疾病活动度及严重程度无明显相关。sST2水平的升高可能是IL-33介导的炎症反应和免疫应答的负反馈调节机制。Objective:To investigate the clinical significance of interleukin-33(IL-33)and soluble ST2(sST2)in patients with vitiligo.Methods:The serum concentrations of IL-33 and sST2 were determined by enzyme linked immunosorbent assay(ELISA)respectively in 62 patients with vitiligo and 30 healthy controls.The levels of IL-33 and sST2 in patients in different disease stage,clinical course and lesion area were assessed.Results:The expression levels of serum IL-33 and sST2 were higher in peripheral blood of patients in progressive stage and stable stage of vitiligo than those in the normal controls(IL-33:t=4.67,2.34,P=0.004,0.031,respectively;sST2:t=3.59,2.09,P=0.027,0.045,respectively).The level of sST2 in the abnormal autoantibody group of patients with vitiligo was significantly higher than that in the non-abnormal autoantibody group(t=2.46,P=0.015).There was no significant differences of IL-33 and sST2 for gender,white spot area,family history,mental stress,and clinical microelement(all P>0.05).Serum IL-33 or sST2 did not significantly correlate with age or disease duration in patients with vitiligo(all P>0.05).Conclusions:IL-33 and sST2 may play an important role in the pathogenesis of vitiligo.

关 键 词：白癜风 白细胞介素33 可溶性受体ST2 

分 类 号：R758.4+1[医药卫生—皮肤病学与性病学]