异基因造血干细胞移植后出血性膀胱炎及BK、JC病毒感染  

Hemorrhagic cystitis and infection of BK and JC virus after allogeneic hematopoietic stem cell transplantation

作　　者：杨蕊雪 陈刚[1] 玛丽娅·木哈什[1] 古力巴旦木·艾则孜 丁凌陆[1] 张乐[1] 张友弟 袁海龙[1] Yang Ruixue;Chen Gang;Maliya·Muhashi;Gulibadanmu·Aizezi;Ding Linglu;Zhang Le;Zhang Youdi;Yuan Hailong(The First Department of Hematology Center,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054)

机构地区：[1]新疆医科大学第一附属医院血液病中心一科,新疆乌鲁木齐830054

出　　处：《中国社区医师》2021年第2期72-73,共2页Chinese Community Doctors

基　　金：新疆维吾尔自治区自然科学基金项目(2017D01C297)。

摘　　要：目的:了解异基因外周血造血干细胞移植后出血性膀胱炎(HC)的发生情况及BK与JC病毒感染情况。方法:选取2019年1-12月行异基因造血干细胞移植且发生出血性膀胱炎的患者54例,分析HC的发生情况。结果:迟发型出血性膀胱炎(LOHC)累计发生率为29.6%,单倍体42例LOHC累计发生率为34.6%。患者血及尿BK、JC病毒DNA检测,Ⅳ度为阴性1例,因新冠肺炎疫情影响未行病毒检测2例,其余14例患者均为阳性。结论:HC是异基因外周血造血干细胞移植后常见并发症,单倍体造血干细胞移植是其发生的独立危险因素,BK及JC病毒感染与HC发生直接相关。Objective:To investigate the incidence of hemorrhagic cystitis(HC)and the infection of BK and JC virus after allogeneic peripheral blood stem cell transplantation.Methods:From January to December 2019,54 patients with hemorrhagic cystitis who underwent allogeneic hematopoietic stem cell transplantation were selected to analyze the occurrence of HC.Results:The cumulative incidence of delayed hemorrhagic cystitis(LOHC)was 29.6%,and the cumulative incidence of LOHC in 42 haploid cases was 34.6%.The DNA detection of BK and JC virus in blood and urine of the patient showed that 1 case was negative for gradeⅣ,2 cases were not detected for virus due to the influence of COVID-19 epidemic situation,and the other 14 patients were all positive.Conclusion:HC is a common complication after allogeneic peripheral blood stem cell transplantation.Haploid hematopoietic stem cell transplantation is an independent risk factor for its occurrence.BK and JC virus infection are directly related to the occurrence of HC.

关 键 词：出血性膀胱炎 异基因造血干细胞移植 BK病毒 JC病毒 

分 类 号：R457.7[医药卫生—治疗学] R694.3[医药卫生—临床医学]