磺酰肼和二硫缩烯酮区域选择性环化反应合成3-烷硫基取代吡唑  

Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals

作　　者：李毅 万结平[1] Li Yi;Wan Jieping(College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022)

机构地区：[1]江西师范大学化学化工学院,南昌330022

出　　处：《有机化学》2020年第11期3889-3894,M0012,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21861019)资助项目.

摘　　要：以磺酰肼和二硫缩烯酮为起始物,在廉价易得的硫酸氢钠作为催化剂条件下,建立了二者之间区域选择性环化合成3-烷硫基取代的吡唑类化合物的方法.在1,4-二氧六环作为介质和80℃加热条件下进行,高效合成了一系列N-磺酰基结构的3-烷硫基吡唑化合物.By using sulfonyl hydrazines and ketene dithioacetals as starting materials, the regioselective annulation providing 3-alkylthiolated pyrazoles has been realized in the low cost and easily available NaHSO4 catalytst. The reactions were realized in 1,4-dioxane medium and 80 ℃ heating, whereby a seris of 3-alkylthiol pyrazoles possessing N-sulfonyl structure have been efficiently synthesized.

关 键 词：二硫缩烯酮 磺酰肼 环化 区域选择性 3-烷硫基吡唑 

分 类 号：O626.21[理学—有机化学]