干细胞治疗压力性尿失禁的适用性  

Applicability of stem cells in the treatment of stress urinary incontinence

作　　者：任腾洲 陈杰 赵伟 陈智威 张腾 王彦 Ren Tengzhou;Chen Jie;Zhao Wei;Chen Zhiwei;Zhang Teng;Wang Yan(Department of Urology,the Third Affiliated Hospital(Zunyi First People’s Hospital)of Zunyi Medical University,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医科大学第三附属医院(遵义市第一人民医院)泌尿外科,贵州省遵义市563000

出　　处：《中国组织工程研究》2021年第25期4058-4064,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81660121),项目负责人:王彦。

摘　　要：背景:压力性尿失禁是下尿路的常见疾病之一,目前的治疗方式只能症状缓解,而不能将其治愈。现以干细胞为基础的细胞注射疗法实现了对自体细胞的使用,并且能够针对尿失禁的病因进行治疗。目的:综述近年来国内外关于各种类型干细胞治疗女性压力性尿失禁的研究进展。方法:计算机检索中国知网、万方数据库、维普网和PubMed数据库2005至2020年的相关文献,中文检索词为"干细胞,压力性尿失禁";英文检索词为"stem cells,stress urinary incontinence",选择与干细胞治疗压力性尿失禁方面的相关文章,并对各种类型干细胞在压力性尿失禁治疗中的应用进行总结、整理和论述。结果与结论:在所有关于干细胞治疗压力性尿失禁的研究中,肌源性干细胞和脂肪干细胞被运用的最多,它们能够支持与压力性尿失禁相关的靶组织再生,其主要是通过治疗功能失调的括约肌来恢复其原有功能。大多数研究表明干细胞治疗压力性尿失禁有很大的潜力,有望更多关于干细胞治疗压力性尿失禁的基础研究能转化为临床应用,使压力性尿失禁成为可以被治愈的疾病。BACKGROUND:Stress urinary incontinence is one of the most common diseases of the lower urinary tract.Current treatment methods can only relieve symptoms,but cannot completely cure them.Regenerative medicine based on stem cells realizes the use of autologous cells,and its purpose is to treat the cause of urinary incontinence.OBJECTIVE:To summarize the application of various types of stem cells in the treatment of female stress urinary incontinence in and outside China in recent years.METHODS:Computer search of the CNKI,Wanfang,VIP,and PubMed databases from 2005 to 2020 was conducted.The search terms were“stem cells,stress urinary incontinence”in Chinese and English.Articles related to stem cells in the treatment of stress urinary incontinence were selected.The application of various types of stem cells in the treatment of stress urinary incontinence was summarized,organized,and discussed.RESULTS AND CONCLUSION:In all the studies on stem cell treatment of stress urinary incontinence,muscle derived stem cells and adipose derived stem cells are most used.They can support the regeneration of target tissues related to stress urinary incontinence patients.The main purpose is to restore its original function by treating the dysfunctional sphincter.Most studies have shown that stem cells have great potential in treating stress urinary incontinence.It is hoped that more basic research on stem cell treatment of stress urinary incontinence can be transformed into clinical applications,making stress urinary incontinence a disease that can be cured.

关 键 词：干细胞 间充质干细胞 脂肪干细胞 骨髓间充质干细胞 肌源性干细胞 压力性尿失禁 固有括约肌缺陷 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]