人羊膜上皮细胞在妇产科领域的研究、应用及发展  

Research,application and development of human amniotic epithelial cells in the field of obstetrics and gynecology

作　　者：王璇[1] 周超[1] 张英姿[1] Wang Xuan;Zhou Chao;Zhang Yingzi(Department of Gynecology,Binzhou Medical University Hospital,Binzhou 256603,Shandong Province,China)

机构地区：[1]滨州医学院附属医院妇科,山东省滨州市256603

出　　处：《中国组织工程研究》2021年第25期4070-4075,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:人羊膜上皮细胞具有广泛的生物学作用,可应用于多种疾病的治疗,如结膜损伤、烧伤、肺纤维化及心脏疾病等;人羊膜上皮细胞在妇产科领域研究已进行了动物实验并取得显著成果,有望成为新的疾病治疗方法,值得进行深入研究和探索。目的:综述人羊膜上皮细胞在妇产科领域的研究进展、应用现状及发展前景。方法:以"human amniotic epithelial cells""tumor""obstetrics and gynecology"为英文检索词检索PubMed、Web of Science数据库,以"人羊膜上皮细胞""妇科肿瘤""妇产科"为检索词检索万方、CNKI中文数据库,按纳入排除标准共纳入40篇文献进行归纳总结。结果与结论:①人羊膜上皮细胞逆转子宫内膜癌异常血管结构和功能并诱导癌细胞凋亡;②人羊膜上皮细胞可抑制化疗诱导的颗粒细胞凋亡,恢复生育能力;③人羊膜上皮细胞可以治疗宫腔粘连,提高生育力;④人羊膜上皮细胞可治疗复发性自然流产。相信随着研究的进一步深入,人羊膜上皮细胞的功能将会得到更广泛的开发和利用。BACKGROUND: Human amniotic epithelial cells have a wide range of biological functions and can be used in the treatment of many diseases, such as conjunctival injury, burn, pulmonary fibrosis and heart disease. Human amniotic epithelial cells have been tested in the field of obstetrics and gynecology and achieved remarkable results, which is expected to become a new disease treatment, and is worthy of in-depth research and exploration.OBJECTIVE: To review the research progress, application status and development prospect of human amniotic epithelial cells on some diseases in the field of gynecology and obstetrics.METHODS: Key words "human amniotic epithelial cells", "tumor" and "obstetrics and gynecology" were used to search PubMed and Web of Science databases, and Wanfang and CNKI Chinese databases were searched with key words "human amniotic epithelial cells", "gynecological tumor" and "obstetrics and gynecology". A total of 40 articles were included according to the inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1) Human amniotic epithelial cells reverse abnormal vascular structure and function and induce apoptosis of endometrial carcinoma.(2) Human amniotic epithelial cells can inhibit apoptosis of granulosa cells induced by chemotherapy and restore fertility.(3) Human amniotic epithelial cells can treat uterine adhesion and improve fertility.(4) Human amniotic epithelial cells can treat recurrent spontaneous abortion. It is believed that with the further research, the function of human amniotic epithelial cells will be more widely developed and utilized.

关 键 词：人羊膜上皮细胞 凋亡 卵巢功能 宫腔粘连 复发性流产 妇科肿瘤 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]