子午流注穴位电刺激对卵巢低反应患者辅助生殖结局的影响  

Effect of low frequency treatment of midnight⁃noon ebb⁃flow acupuncture on assisted reproductive out⁃comes in poor ovarian responders

作　　者：刘娟 陆杉 王小云 LIU Juan;LU Shan;WANG Xiaoyun(Department of Reproductive Medi-cine,Guangzhou University of TCM Second Hospital,Guangzhou 510006,China;不详)

机构地区：[1]广州中医药大学第二附属医院生殖医学科,广州510006 [2]广州中医药大学第二附属医院妇科,广州510006

出　　处：《实用医学杂志》2020年第24期3434-3439,共6页The Journal of Practical Medicine

基　　金：广东省中医药局科研项目(编号:20181138);国家中医药管理局项目:王小云全国名老中医药专家传承工作室(编号:16MLZY02);广东省中医药局科研项目(编号:20194007);广东省中医院项目:岭南妇科流派传承工作室(编号:E43605)。

摘　　要：目的探讨子午流注穴位电刺激对辅助生育治疗中卵巢低反应患者卵巢储备功能和妊娠结局的影响。方法将拟行体外受精(in vitro fertilization,IVF)治疗的70例卵巢低反应患者,分为2组(观察组和空白对照组)。观察组在IVF治疗前行子午流注穴位电刺激2个月经周期,对照组则直接进行IVF治疗。比较观察组患者治疗前后卵巢功能参数以及两组后续行IVF治疗的基本临床资料、临床用药、卵子数量、胚胎质量及妊娠结局。结果经过子午流注穴位电刺激治疗后,观察组的基础窦卵泡数显著高于治疗前(P=0.002),基础卵泡刺激素显著低于治疗前(P=0.011),观察组患者的获卵数及可利用胚胎数均显著高于对照组(P<0.05),观察组患者临床妊娠率及活产率均高于对照组(44.4%vs.29.2%)(29.6%vs.12.5%),但差异无统计学意义。结论辅助生育治疗前行子午流注穴位电刺激能明显改善卵巢低反应患者的卵巢储备功能并增加获卵数及可利用胚胎数,为改善IVF治疗结局提供了新的治疗方案。Objective To observe the effect of low frequency treatment of midnight⁃noon ebb⁃flow acu⁃puncture on ovarian reserve function and pregnancy outcome in patients with poor ovarian response treated with vitro fertilization⁃embryo transfer.Methods 70 patients who were to undergo in vitro fertilization(IVF)were randomly divided into the observation group and the control group,the former treated with low⁃frequency treatment of midnight⁃noon ebb⁃flow acupuncture for 2 menstrual cycles before IVF and the latter only with IVF.The changes of ovarian function before and after treatment were compared within the observation group and the data of basic clinical information,exogenous administration,oocyte,embryo information and pregnant outcome between the two groups were compared.Result After the low frequency treatment of midnight⁃noon ebb⁃flow acupuncture,the basic AFC was significantly higher than before the treatment(P=0.002),the basic FSH was lower significantly(P=0.011).The numbers of oocytes retrieved and embryos available in the observation group were significantly higher than those of the control group(P<0.05).The clinical pregnant rate and live birth rate were higher than those of the control group(44.4%vs.29.2%),(29.6%vs.12.5%).Conclusion The low⁃frequency treatment of midnight⁃noon ebb⁃flow acupuncture before IVF can significantly improve the ovarian reserve function,increase the number of oocytes and embryos available,and improve the outcome of IVF treatment.

关 键 词：卵巢低反应 子午流注穴位电刺激 辅助生育治疗 

分 类 号：R711.6[医药卫生—妇产科学]