生殖损害和不良妊娠结局的环境、生活方式和心理危险因素研究进展及展望  

Progress and prospective of environmental, lifestyle and psychological risk factors for reproductive impairment and adverse birth outcome

作　　者：曹佳[1] 陈卿[1] CAO Jia;CHEN Qing(Institute of Toxicology,Faculty of Military Preventive Medicine,Army Medical University(Third Military Medical University),Chongqing,400038,China)

机构地区：[1]陆军军医大学(第三军医大学)军事预防医学系毒理学研究所,重庆400038

出　　处：《第三军医大学学报》2021年第1期1-9,共9页Journal of Third Military Medical University

基　　金：重庆市技术创新与应用示范专项(CSTC2018jscx-mszdX0021);国家重点研发计划(2017YFC1002001);国家自然科学基金重点项目(81630087)。

摘　　要：生殖损害和不良妊娠结局是我国卫生健康领域当前面临的重要挑战。识别、鉴定相关危险因素、阐明其作用机制对于制定有效的防控策略至关重要。本文从环境因素、生活方式因素、心理因素等方面,探讨相关危险因素的研究进展。当前的研究除了对环境内分泌干扰物、重金属等已知危险因素的认识在不断深入,也在逐渐揭示PM2.5、昼夜节律紊乱、慢性心理应激等为代表的大量新的潜在危险因素的损害效应及其机制。而对生殖系统发育和功能维持机制的新认识,以及多组学技术、毒性机制研究新范式和队列研究的兴起,可能为未来生殖损害和不良妊娠结局防治研究提供新的机遇和方向。Nowadays,reproductive impairment and adverse birth outcome are emerging major health challenges in China.Effective prevention strategies for these problems substantially depend on the identification of the related risk factors in the population and on the understanding of their underlying mechanisms.In this review,we discuss the potential risk factors in environmental,lifestyle and psychological aspects.Besides the further profound understanding of known risk factors,such as environmental endocrine disruptors and heavy metals,the roles and mechanisms of some novel factors,including PM2.5,circadian disruption and chronic stress,were also unveiled.New knowledge and techniques,especially the findings in the mechanism of reproductive system development and functioning,multi-omics methods,novel toxicity testing strategy and cohort study may provide brand new opportunities and inspirations for future researches on the prevention and treatment of reproductive impairment and adverse birth outcome.

关 键 词：生殖损害 不孕 出生缺陷 疾病风险 危险因素 

分 类 号：R339.2[医药卫生—人体生理学]