Effects of Micro-Milling and Laser Engraving on Processing Quality and Implantation Mechanics of PEG-Dexamethasone Coated Neural Probe  

作　　者：ZHOU Xuhui ZHANG Wenguang XIE Jie 周旭晖;张文光;谢颉(State Key Laboratory of Mechanical System and Vibration,School of Mechanical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]State Key Laboratory of Mechanical System and Vibration,School of Mechanical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Journal of Shanghai Jiaotong university(Science)》2021年第1期1-9,共9页上海交通大学学报（英文版）

基　　金：the National Natural Science Foundation of China(No.51675330)。

摘　　要：Compared with stiff silicon-based probes,flexible neural probes can alleviate biological inflammation and tissue rejection.A polyethylene glycol(PEG)coating can facilitate the insertion of flexible probes,and the fabrication methods have a significant impact on the dimensional accuracy and structural strength of the coating.In this study,a novel melting injection moulding method is used to process a PEG-dexamethasone(PEG-DEX)coating with high structural strength for a type of mesh-shaped photosensitive polyimide(PSPI)based neural probe.Combined with the digital image correlation(DIC)method,an in vitro test system with high accuracy is developed to evaluate the effects of the elastic modulus of the PEG component and two fabrication methods,i.e.,computer-numerical-control(CNC)micro-milling and laser engraving,on the processing quality and implantation mechanics of a PEG-DEX coated probe.The results show that compared with laser engraving,CNC micro-milling can ensure high dimensional accuracy and sharpness for the composite coating,thus leading to small damage from implantation,whereas the elastic modulus of the composite coating has a limited effect on the implantation mechanics of the PEG-DEX coated probe.

关 键 词：flexible neural probe composite coating digital image correlation(DIC) polyethylene glycol(PEG) dexamethasone(DEX) insertion force implantation injury 

分 类 号：R318.01[医药卫生—生物医学工程]