Blood Pressure Change in Intrafascicular Vagal Activities  

作　　者：GUO Jinyao LI Runhuan WANG Jiaojiao ARRANZ Javier LI Yiran CHAI Xinyu WANG Jiguang SUI Xiaohong 郭金尧;李润桓;王娇娇;A RRANZ Jarier;李怡然;柴新禹;王继光;隋晓红(School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Shanghai Institute of Hypertension,Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,Jiangsu,China)

机构地区：[1]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [2]Shanghai Institute of Hypertension,Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,Jiangsu,China

出　　处：《Journal of Shanghai Jiaotong university(Science)》2021年第1期47-54,共8页上海交通大学学报（英文版）

基　　金：the Innovation Studio from School of Biomedical Engineering,Shanghai Jiao Tong University,and the Medical-Engineering Cross Project of Shanghai Jiao Tong University(No.YG2017MS53)。

摘　　要：Baroreflex plays a significant role in modulating blood pressure for the human body.It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure.However,how the vagal activities quantitatively relate with blood pressure can hardly be achieved.Here fine carbon nanotube yarn(CNTy)electrodes were adopted for recording intrafascicular vagal activities,synchronized with measurement of arterial blood pressure in a rat.Together with a novel algorithm,the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities,and the number of individual vagal spikes correspondingly varied with blood pressure.Especially for Cluster 2,the neural activations decreased with arterial blood pressure increasing.This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure,and guide the vagal-nerve neuromodulation for treating hypertension.

关 键 词：vagal nerve HYPERTENSION BAROREFLEX signal processing NEUROMODULATION carbon nanotube yarn(CNTy)electrodes 

分 类 号：R318[医药卫生—生物医学工程]