多中心网状组织细胞增生症1例  

A Case of Multicentric Reticulohistiocytosis

作　　者：薛燕 聂舒 胡芳 毕新岭 XUE Yan;NIE Shu;HU Fang;BI Xinling(Department of Dermatology,Changhai Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学附属长海医院皮肤科,上海200433

出　　处：《中国皮肤性病学杂志》2021年第1期66-69,共4页The Chinese Journal of Dermatovenereology

基　　金：上海市浦江人才计划(18PJD053);中国中西医结合学会皮肤性病分会澳美基金(2018)。

摘　　要：患者女,55岁,面颈部皮疹1年,指关节变形6个月。皮肤科情况:面颈部、耳廓弥漫性红斑,以曝光部位为主;鼻周散在黄红色丘疹,无破溃。齿龈见红色丘疹,前胸V字区见水肿性红斑,无水疱。双手X线片示近节及远节指间关节均有不同程度破坏,致使关节畸形,软组织肿胀。鼻翼皮损组织病理示:真皮内大量组织细胞及嗜酸性胞浆的多核巨细胞浸润。免疫组织化学染色示:CD68(+)、S100(-)、CD1a(-)。诊断:多中心网状组织细胞增生症。经雷公藤治疗1个月后症状轻度好转。A 55-year-old female presented with cutaneous lesions on the face and neck for 1 year,and deformity of the finger joints for 6 months.Dermatological examination showed that diffuse erythema on the face,neck and bilateral helix,mainly in light exposed areas.There were scattered yellow-red papules around the nose,without ulceration.Red papules were seen on the gums,and the edematous erythema in the V-shaped area of the front chest,without blisters.X-rays of both hands revealed that the proximal and distal interphalangeal joints were destructive in different degrees,resulting in joint deformities and soft tissue swelling.Histopathology of skin lesions on the nose showed that a large number of histiocytes in the dermis and multinucleated giant cells of eosinophilic cytoplasm were infiltrated.Immunohistochemical staining showed CD68(+),S100(-),CD1a(-).The diagnosis of multicentric reticulohistiocytosis was made.The patient was treated with Tripterygium wilfordii,the clinical symptoms were slightly improved after one month.

关 键 词：多中心网状组织细胞增生症 皮肌炎 类风湿性关节炎 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]