血清载脂蛋白A1、B水平与冠心病患者冠状动脉病变支数和Gensini积分的相关性分析  

Correlation Analysis of Serum Apolipoprotein A1,B levels with the Number of Coronary Artery Lesions and Gensini Score in Patients with Coronary Heart Disease

作　　者：邹金国 陈小强 徐睿 ZOU Jin-guo;CHEN Xiao-qiang;XU Rui(The Third Hospital of Xi'an City,Shanxi Province,710000)

机构地区：[1]陕西省西安市第三医院,陕西西安710000 [2]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《医学临床研究》2020年第12期1853-1855,共3页Journal of Clinical Research

摘　　要：【目的】探讨冠心病(CHD)患者血清载脂蛋白A1(ApoA 1)、载脂蛋白B(ApoB)与冠状动脉病变支数、Gensini积分的相关性。【方法】选择2016年3月至2018年10月在西安市第三医院和新疆自治区人民医院治疗的300例CHD患者,其中急性心肌梗死86例(AMI组)、不稳定型心绞痛102例(UAP组)、稳定型心绞痛112例(SAP组)。采用免疫透射比浊法检测血清ApoA1、ApoB水平,计算所有患者Gensini积分,比较三组患者血清ApoA1、ApoB水平,并分析血清AopA1和ApoB水平与Gensini积分的相关性。【结果】SAP组患者血清AopA1水平最高,UAP组患者次之,AMI组患者最低;AMI组患者血清ApoB水平最高,UAP组患者次之,SAP组患者最低,其差异均有统计学意义(P<0.05)。AMI组患者冠状动脉多支病变所占比例及Gensini积分最高,UAP组次之,SAP组最低,差异有统计学意义(P<0.05)。Pearson分析显示,AopA1与冠状动脉病变支数和Gensini积分呈负相关(r=-0.690、-0.653,P<0.001),而ApoB与之呈正相关(r=0.713、0.685,P<0.001)。【结论】CHD患者血清ApoA1、ApoB水平与冠状动脉病变支数及Gensini积分相关。【Objective】To analyze the correlation between serum apolipoprotein A1(ApoA 1)and B(ApoB)and the number of coronary artery lesions and Gensini score in coronary heart disease(CHD).【Methods】A total of 300 cases of CHD patients treated in Xi'an Third Hospital and People's Hospital of Xinjiang Autonomous Region from March 2016 to October 2018 were selected and divided into acute myocardial infarction(AMI)group(n=86),unstable angina pectoris(UAP)group(n=102),stable angina group(SAP)group(n=112).Coronary artery lesions were examined by angiography and Gensini score was performed.The serum ApoA 1 and ApoB were detected.The correlation between serum levels of apolipoprotein A1 and B and the number of coronary artery lesions and Gensini score was analyzed.【Results】The serum AopA1 level of the SAP group was the highest,the UAP group was the second,the AMI group was the lowest;the serum ApoB level of the AMI group was the highest,the UAP group was the second,the SAP group was the lowest,the differences were statistically significant(P<0.05).The proportion of multi vessel lesions and Gensini score of the AMI group were the highest,the UAP group was the second,the SAP group was the lowest,the difference was statistically significant(P<0.05).Pearson analysis showed that AopA1 was negatively correlated with the number of coronary artery lesions and Gensini score(r=-0.690,-0.653,P<0.001),while ApoB was positively correlated with it(r=0.713,0.685,P<0.001).【Conclusion】Serum ApoA1 and apoB levels are correlated with the number of coronary artery lesions and Gensini score in CHD patients.

关 键 词：冠心病 脂蛋白类/血液 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]