二氢-β-沉香呋喃型倍半萜类天然产物衍生物的化学研究  

Chemistry research on natural product derivatives of dihydro-β-agarofuran sesquiterpenoids

作　　者：宁若男 徐佳琦 徐一新 NING Ruo-nan;XU Jia-qi;XU Yi-xin(College of Pharmacy,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Department of Pharmacy,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海健康医学院药学院,上海201318 [2]上海中医药大学附属龙华医院药剂科,上海200032

出　　处：《中国中药杂志》2020年第23期5712-5721,共10页China Journal of Chinese Materia Medica

基　　金：上海卫健委青年项目(20184Y0138);上海市2020年度“科技创新行动计划”扬帆计划项目(20YF1418300)。

摘　　要：二氢-β-沉香呋喃型倍半萜具有化学多样性和生物多样性。对卫矛科卫矛属植物桃叶卫矛的粗提物进行碱水解,获得仅含羟基的二氢-β-沉香呋喃型倍半萜底物,产率高达0.4%。再通过酯化、氧化以及脱羧等反应合成12个衍生物。综合利用1H-NMR、13C-NMR、质谱及X-单晶衍射进行结构鉴定。其中11个为新化合物。此次衍生化探索为今后二氢-β-沉香呋喃型倍半萜的化学研究提供了参考依据。Dihydro-β-agarofuran sesquiterpenoids possess chemical diversity and biodiversity.A dihydro-β-agarofuran sesquiterpenoid with only hydroxyl groups has been prepared by basic hydrolysis of crude extract of Euonymus bungeanus with 0.4% yield.Twelve derivatives were available in esterification,oxidation,decarboxylation,etc.Extensive 1H-NMR,13C-NMR,MS spectroscopic analyses and single-crystal X-ray diffraction analysis with Cu Kαradiation indicated that eleven derivatives were new compounds.The results will provide reference for chemistry study on natural product derivatives of dihydro-β-agarofuran sesquiterpenoids.

关 键 词：二氢-β-沉香呋喃型倍半萜 碱水解 桃叶卫矛 

分 类 号：R284[医药卫生—中药学]