复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症的临床研究  

Clinical study of Fuming Capsules combined with Polyethylene Glycol Eye Drops in treatment of dry eye after cataract surgery

作　　者：唐耀冰 邢艳巧 郝娟[1] 史勇洪[1] 赵倩[1] 张相冉 TANG Yao-bing;XING Yan-qiao;HAO Juan;SHI Yong-hong;ZHAO Qian;ZHANG Xiang-ran(Department of Ophthalmology,Puyang People’s Hospital,Puyang 457001,China)

机构地区：[1]濮阳市人民医院眼科,河南濮阳457001

出　　处：《现代药物与临床》2020年第12期2405-2409,共5页Drugs & Clinic

基　　金：河南省医学科技攻关计划项目(201603282)。

摘　　要：目的探讨复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症的临床疗效。方法选取2017年8月—2019年12月濮阳市人民医院收治的93例白内障术后干眼症患者(142眼)。根据信封法将所有患者分为对照组(46例,69眼)和治疗组(47例,73眼)。对照组患者滴眼聚乙二醇滴眼液,3次/d。治疗组在对照组治疗的基础上口服复明胶囊,5粒/次,3次/d。两组连续治疗8周。观察两组的临床疗效,比较两组泪液肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、角膜荧光素染色(FL)评分、泪液分泌试验(Sit)长度、泪膜破裂时间(BUT)和干眼症状评分。结果治疗后,治疗组总有效率为89.04%,显著高于对照组的73.91%,差异有显著性意义(P<0.05)。治疗后,两组FL评分下降,BUT、Sit长度升高(P<0.05);且治疗组FL评分低于对照组,BUT、Sit长度高于对照组(P<0.05)。治疗4、8周后,两组干眼症状评分均显著下降(P<0.05),并且治疗组干眼症状评分低于同期对照组(P<0.05)。治疗后,两组泪液TNF-α、IL-6、hs-CRP水平均明显下降(P<0.05),并且治疗组泪液TNF-α、IL-6、hs-CRP水平低于对照组(P<0.05)。结论复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症疗效确切,可有效改善其临床症状,有效降低泪液TNF-α、IL-6、hs-CRP水平,安全性较好。Objective To investigate the clinical effect of Fuming Capsules combined with Polyethylene Glycol Eye Drops in treatment of dry eye after cataract surgery.Methods Patients(93 cases,142 eyes)with dry eye after cataract surgery in Puyang People’s Hospital from August 2017 to December 2019 were enrolled in this study.According to envelope method,patients were randomly divided into the control group(46 cases,69 eyes)and the treatment group(47 cases,73 eyes).Patients in the control group were given Polyethylene Glycol Eye Drops,three times daily.Patients in the treatment group were po administered with Fuming Capsules on the basis of the control group,5 grains/time,three times daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical efficacies were evaluated,and TNF-α,IL-6,and hs-CRP of tears,FL score,Sit long,and BUT in two groups were compared.Results After treatment,the total effective rate of the treatment group was 89.04%,which was significantly higher than that of the control group(73.91%),and the difference was significant(P<0.05).After treatment,FL score of two groups was decreased,but BUT and Sit length of two groups were increased(P<0.05).And FL score of the treatment group was lower than that of the control group,but BUT and Sit length of the treatment group were higher than that of the control group(P<0.05).After treatment for 4 and 8 weeks,the dry eye symptom scores of two groups were significantly decreased(P<0.05),and the dry eye symptom scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of TNF-α,IL-6,and hs-CRP in two groups were significantly decreased(P<0.05),and the levels of TNF-α,IL-6,and hs-CRP in the treatment group were lower than those in the control group(P<0.05).Conclusion Fuming Capsules combined with Polyethylene Glycol Eye Drops is effective in treatment of dry eye after cataract surgery.It can effectively improve the clinical symptoms and effectively reduce the levels of TNF-α,IL-6,and hs-CRP in tear

关 键 词：复明胶囊 聚乙二醇滴眼液 白内障术后干眼症 临床症状 泪液指标 干眼症状评分 

分 类 号：R988.1[医药卫生—药品]