乳制品摄入与儿童左心室肥厚的关联  

Association of dairy intake frequency with left ventricular hypertrophy in childhood

作　　者：李紫琳 张艳青[2] 张茜[2] 马传伟 赵敏 席波 Li Zilin;Zhang Yanqing;Zhang Qian;Ma Chuanwei;Zhao Min;Xi Bo(Department of Epidemiology,School of Public Health,Cheeloo College of Medicine,Shandong University/Children Cardiovascular Research Center of Shandong University,Ji′nan 250012,China;Department of Food Nutrition and Child Health Care,Zibo Center for Diseases Prevention and Control,Zibo 255026,China;Department of Toxicology and Nutrition,School of Public Health,Cheeloo College of Medicine,Shandong University,Ji′nan 250012,China)

机构地区：[1]山东大学齐鲁医学院公共卫生学院流行病学系,山东大学儿童心血管研究中心,济南250012 [2]淄博市疾病预防控制中心食品营养与学生保健所,255026 [3]山东大学齐鲁医学院公共卫生学院毒理与营养学系,济南250012

出　　处：《中华预防医学杂志》2020年第12期1389-1395,共7页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81673195、81722039)。

摘　　要：目的探讨儿童乳制品摄入频率与左心室肥厚(LVH)的关联。方法研究对象来源于在山东省淄博市桓台县开展的“桓台儿童心血管健康随访队列”。采用方便整群抽样的方法,于2017年11月至2018年1月在桓台县某所小学选取1515名6~11岁儿童进行基线调查,将问卷调查、体格检查、超声检查和实验室检测等信息均完整的1237名儿童纳入研究。根据乳制品摄入频率,将研究对象分为5组(从不、≤3次/月、1~2次/周、3~5次/周和几乎每天),采用多元线性回归及趋势卡方检验探讨LVMI水平及LVH检出率随乳制品摄入频率的变化趋势,采用多因素logistic回归模型分析乳制品摄入频率与儿童LVH的关系。结果1237名研究对象的年龄为(8.4±1.6)岁,其中男童655名(53.0%)。随着乳制品摄入频率的增加,儿童LVMI水平及LVH检出率均呈下降趋势(P趋势<0.05)。调整混杂因素后,与从不摄入乳制品相比,1~2次/周(OR=0.27,95%CI:0.09~0.82)、3~5次/周(OR=0.33,95%CI:0.12~0.91)和几乎每天摄入(OR=0.22,95%CI:0.09~0.54)者LVH检出风险较低。结论乳制品摄入频率与儿童LVH有关联,每周摄入1次以上乳制品的儿童出现LVH的可能性较小。Objective To examine the association between dairy intake frequency and left ventricular hypertrophy(LVH)in childhood.Methods Data were obtained from Huantai Childhood Cardiovascular Health Cohort study in Huantai County,Zibo City,Shandong Province.A convenient cluster sampling method was used to conduct a baseline survey on 1515 children aged 6-11 years old in a primary school from November 2017 to January 2018.A total of 1237 children who had complete data on questionnaire,physical,ultrasound and laboratory examinations were included for analysis.The frequency of dairy intake was divided into five groups(never,≤3 times/month,1-2 times/week,3-5 times/week and nearly every day).Multivariate linear regression models and chi‑square trend test were used to examine the trend in level of LVMI and prevalence of LVH,respectively.With the increase of dairy intake frequency,and multivariate logistic regression models were used to evaluate the association between dairy intake frequencies and LVH in childhood.Results The age of children was(8.4±1.6)years,and the number of boys was 655(53.0%).There was no significant difference in LVMI levels among different frequencies of dairy intake(P>0.05).With the increase of dairy intake frequencies,the level of LVMI and the prevalence of LVH decreased significantly(P for trend<0.05).After the adjustment of potential covariates,compared with no dairy intake group,children who consumed dairy products 1-2 times/week(OR=0.27,95%CI:0.09-0.82),3-5 times/week(OR=0.33,95%CI:0.12-0.91)and almost every day(OR=0.22,95%CI:0.09-0.54)had a lower risk of LVH.Conclusion Dairy intake frequency is associated with LVH in childhood,and children who consume dairy products frequently(more than once a week)are less likely to have LVH.

关 键 词：儿童 肥大 左心室 横断面研究 乳制品摄入 

分 类 号：R725.4[医药卫生—儿科]