2009-2010年上海市50岁及以上人群握力、快速步行速度与认知功能的关联性研究  

Association between grip strength,rapid gait speed and cognition in people aged 50 and above in Shanghai during 2009-2010

作　　者：阮晔[1] 施燕[1] 郭雁飞[1] 孙双圆 黄哲宙[1] 王玉琢 郑杨[1] 吴凡 Ruan Ye;Shi Yan;Guo Yanfei;Sun Shuangyuan;Huang Zhezhou;Wang Yuzhuo;Zheng Yang;Wu Fan(Division of Chronic Noncommunicable Disease and Injury,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Office for Shanghai Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]上海市疾病预防控制中心慢性非传染病与伤害防治所,200336 [2]复旦大学上海医学院办公室,200032

出　　处：《中华预防医学杂志》2020年第12期1414-1420,共7页Chinese Journal of Preventive Medicine

基　　金：美国国立老龄研究所资助项目(R01‑AG034479);上海市卫生健康委员会科研项目面上课题(201840118、201640148)、青年课题(20174Y0147);上海市医学领军人才(2019LJ24)。

摘　　要：目的探讨上海市50岁及以上人群握力、快速步行速度和认知功能的关联。方法数据来源于世界卫生组织“全球老龄化与成人健康研究(SAGE)”上海现场第一轮调查,于2009—2010年,采用多阶段随机整群抽样方法,对8643名50岁及以上人群进行问卷调查,并用因子分析法计算认知功能总分。采用两水平线性模型分析握力、快速步行速度和认知功能的关系。结果8175名研究对象年龄为(62.9±9.7)岁,其中男性3782名(46.3%)。握力、快速步行速度平均值分别为(27.46±12.01)kg和(1.44±0.43)m/s,其词语回忆、语言流畅度、顺序数字跨度、倒序数字跨度得分及认知总分分别为(5.72±0.09)、(12.67±0.35)、(6.84±0.10)、(4.32±0.14)和(60.50±0.95)分。在调整年龄、性别、地区、教育水平、婚姻状况、家庭经济水平、慢性病共患情况、BMI、饮酒、吸烟、水果蔬菜摄入和体力活动情况等因素后,握力与词语回忆、语言流畅度、顺序数字跨度、倒序数字跨度和认知总分呈正相关(标化β值分别为0.036、0.079、0.042、0.046和0.043,P<0.05);快速步行速度与词语回忆、语言流畅度和认知总分呈正相关(标化β值分别为0.040,0.031,0.039,P<0.05)。结论握力、快速步行速度与50岁及以上人群认知功能呈正相关,可成为识别老年人认知功能状况的指标。Objective To investigate the association between grip strength,rapid gait speed and cognition in people aged 50 and above in Shanghai.Methods Cross‑sectional data was collected from the World Health Organization(WHO)study on global ageing and adult health(SAGE)wave 1(2009-2010).A questionnaire survey was conducted among 8643 participants aged 50 years old and above selected by using multistage random cluster sampling strategies in Shanghai.Factor analysis was applied to evaluate and generate cognitive function overall score.Association between grip strength,rapid gait speed and cognition was examined by a two‑level hierarchical linear model.Results A total of 8175 participants were included in this study,who were(62.9±9.7)years old,including 3782(46.3%)males.The average grip strength and rapid gait speed of participants were(27.46±12.01)kg and(1.44±0.43)m/s respectively.The average scores of verbal recall(VR),verbal fluency(VF),forward digit span(FDS),backward digit span(BDS)and total cognitive scores were(5.72±0.09),(12.67±0.35),(6.84±0.10),(4.32±0.14)and(60.50±0.95)respectively.Grip strength was positively associated with VR,VF,FDS,BDS and overall cognition(standardized β=0.036,0.079,0.042,0.046 and 0.043 respectively,P<0.05),and rapid gait speed was also positively associated with VR,VF and overall cognition(standardizedβ=0.040,0.031,0.039 respectively,P<0.05)after adjusted for age,sex,residence,education level,marital status,household income,co‑morbidity of chronic conditions,BMI,drinking,smoking,fruits,vegetables intake and physical activities.Conclusion Grip strength and rapid gait speed are both positively associated with cognitive function of people aged 50 and above,which would be indicators to evaluate their cognition.

关 键 词：握力 认知 老年人 横断面研究 步行速度 

分 类 号：R195[医药卫生—卫生统计学]