偶氮染料毒性效应研究进展  

Research advances in the adverse effects of azo dyes

作　　者：邓富昌 王超[1] 顾雯[1] 陈圆圆 韩家骏 杜华茂[3] 彭辉 唐宋 Deng Fuchang;Wang Chao;Gu Wen;Chen Yuanyuan;Han Jiajun;Du Huamao;Peng Hui;Tang Song(China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Department of Chemistry,University of Toronto,ON M5S3H6,Canada;College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,China)

机构地区：[1]中国疾病预防控制中心环境与人群健康重点实验室,中国疾病预防控制中心环境与健康相关产品安全所,北京100021 [2]多伦多大学化学系,M5S3H6 [3]西南大学生物技术学院,重庆400715

出　　处：《中华预防医学杂志》2020年第12期1478-1483,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金青年科学基金(2170070682);中国疾病预防控制中心青年科研基金(2018A201);中国疾病预防控制中心环境所学术带头人启动基金。

摘　　要：中国是世界第一大染料生产和使用国。偶氮染料的大量生产和广泛使用导致环境污染,以及潜在的人体健康风险。环境介质(水、土、气、灰尘等)、食物和服装中的偶氮染料可经多种暴露途径进入人体,部分可代谢生成毒性更强的代谢产物,从而引发过敏反应、肿瘤生成、内分泌干扰等毒性效应。本文综述了偶氮染料的生产使用、环境浓度、人群暴露、毒代动力学、毒性效应及其机制和法规标准,同时展望了偶氮染料的研究趋势。China is the world′s largest producer and user of dyes.The mass production and widespread use of disperse azo dyes led to environmental pollutions and potential human health risks.Azo dyes in environmental media(i.e.,water,soil,air,and dust),food and clothing can enter the human body through multiple exposure routes,and some of them can be metabolized to produce more toxic metabolites,which can trigger toxic effects such as allergic reactions,tumor formation,and endocrine disruptions.This study systematically reviewed the production and use of azo dyes,environmental concentrations,human exposures,toxic effects and their underlying mechanisms,and regulations and standards.Meanwhile,the research trends of azo dyes were also discussed.

关 键 词：毒性作用 致癌物 环境 内分泌干扰物 分散染料 

分 类 号：R114[医药卫生—卫生毒理学]