种间基因渐渗检测方法及其应用研究进展  

Advances in the methods of detecting interspecific gene introgression and their applications

作　　者：程祥 李玲玲 肖钰 陈晓阳 胡新生 CHENG Xiang;LI LingLing;XIAO Yu;CHEN Xiao Yang;HU XinSheng(College of Forestry and Landscape Architecture,South China Agricultural University,Guangzhou 510642,China;Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm,Guangzhou 510642,China)

机构地区：[1]华南农业大学林学与风景园林学院,广州510642 [2]广东省植物种质资源与利用重点实验室,广州510642

出　　处：《中国科学：生命科学》2020年第12期1388-1404,共17页Scientia Sinica(Vitae)

基　　金：中央财政林业改革发展资金项目(批准号:[2018]GDTK-08);华南农业大学人才引进启动项目(批准号:4400-K16013)资助。

摘　　要：伴随着谱系分选进程,从共同祖先群体分裂后形成的子代群体间的基因流逐渐衰减,并可能延续至新物种形成.种间基因组序列差异或种间群体基因频率的变异部分地记录了这些种群历史和当代动态过程,可以根据种间基因组序列变异或基因频率变异推测这些发生过的事件.本文系统探讨了检测种间基因渐渗的方法,包括基于种间群体基因频率变异分析(Fst,LD, STRUCTURE, AFS, TreeMix)和基于种间DNA序列差异分析(ABBA-BABA,IM, IIM, ABC)方法,分析了这些方法的原理和应用局限性,拓展这些方法中的一些重要假设将是今后研究任务之一,包括基因重组效应、区分配子与合子迁移的贡献、交配系统与基因流互作以及适应性基因迁移的阻碍作用.澄清这些影响有助于深入理解物种形成过程.With the proceeding of lineage sorting, gene flow gradually decays among progeny populations that are derived from splitting of a common ancestral population, and may probably continue till the phase of speciation. The differences between interspecific genome sequences or between interspecific population gene frequencies partially record these dynamics of historical and contemporary demography and occurrences, and hence inferences on these events can be attained from analyses of interspecific genomic sequences or gene frequencies. Here, we systematically discussed the methods of detecting interspecific gene introgression, including the approaches based on the differences among interspecific gene frequencies(Fst, LD, STRUCTURE, AFS, TreeMix) and the differences of interspecific DNA sequences(ABBA-BABA, IM, IIM, ABC). We discussed the principles and limits of these methods.Relaxations of some important assumptions underlying these methods remain open questions in the future, including the effects of recombination, the separate contribution of gamete vs. zygote dispersal to gene introgression, the interaction of mating system with gene flow, and the impediment to speciation arising from introgression of adaptive genes. Clarifications of these effects would aid in our deep understanding of the process of speciation.

关 键 词：基因渐渗 物种形成 隔离-迁移模型 谱系分选 基因树 

分 类 号：Q349[生物学—遗传学]