SOS应答对质粒介导的qnr耐药基因表达调控机制的研究进展  

Progress in the regulation of SOS response on plasmid-mediated qnr resistance gene expression

作　　者：杜营彬 王娅[1] 刘佩 李坤洋 邓俊良[1] 左之才[1] 才冬杰 任志华[1] 苟丽萍[1] Du Ying-bin;Wang Ya;Liu Pei;Li Kun-yang;Deng Jun-liang;Zuo Zhi-cai;Cai Dong-jie;Ren Zhi-hua;Gou Li-ping(College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130)

机构地区：[1]四川农业大学动物医学院,成都611130

出　　处：《中国抗生素杂志》2020年第11期1097-1102,共6页Chinese Journal of Antibiotics

摘　　要：SOS应答是普遍存在于细菌中的一种低保真度的DNA修复方式。当细菌DNA受损时,大量的DNA单链堆积,SOS应答启动并诱导远距离基因表达参与DNA修复。此修复过程缺失了DNA复制的校正功能,因此SOS应答会大大增加细菌的基因突变频率从而使细菌能够更快的适应不利环境。另一方面,随着细菌耐药的日益严峻,qnr基因家族成为质粒介导的喹诺酮耐药(plasmid-mediated quinolone resistanc PMQR)研究热点。有报道发现细菌的SOS应答会对菌株的qnr耐药水平造成明显的差异性,完整的SOS应答能够使菌株MIC成倍增加。由此可以怀疑SOS应答对qnr基因的表达存在相应的调控机制,但是相关机制尚未阐明。基于此本文就SOS应答机制和qnr耐药机制二者之间的关系进行试探性的综述。SOS response is a low fidelity DNA repair method commonly found in bacteria. When bacterial DNA is damaged, a large number of single strands of DNA accumulate and SOS response initiates and induces longdistance gene expression to participate in DNA repair. This repair process lacks the correction function of DNA replication, and thus the SOS response can greatly increase the frequency of gene mutation in bacteria so that bacteria can adapt to adverse environment faster. On the other hand, the qnr gene family has become a hotspot of plasmidmediated quinolone resistance(PMQR) research with the increasingly serious situation of bacterial resistance. It has been reported that the bacterial SOS response can cause significant difference in qnr resistance level of the strain, and the complete SOS response can increase the MIC of the strain by several folds. It may be suspected that SOS response regulates qnr gene expression, but there is no report on the mechanism of SOS response regulating qnr resistance in bacteria. Based on this, the relationship between SOS response mechanism and qnr resistance mechanism was tentatively reviewed.

关 键 词：SOS应答 QNR基因 调控机制 细菌耐药 

分 类 号：R978[医药卫生—药品]