基于凋亡理论探讨子宫内膜异位症中医药研究进展  

Research Progress of Traditional Chinese Medicine in Endometriosis Based on Apoptosis Theory

作　　者：丛慧芳[1] 李阳[2] 于洋[1] 张天婵[1,3] CONG Huifang;LI Yang;YU Yang;ZHANG Tianchan(The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China;Heilongjiang University of Chinese Medicine, Harbin 150040, China;Heilongjiang Academy of Chinese Medical Sciences, Harbin 150036, China)

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001 [2]黑龙江中医药大学,黑龙江哈尔滨150040 [3]黑龙江省中医药科学院,黑龙江哈尔滨150036

出　　处：《中医药信息》2021年第2期69-73,共5页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金(81704113);黑龙江省自然科学基金项目(H2015025);黑龙江中医药大学研究生创新科研项目(2019yjscx008)。

摘　　要：子宫内膜异位症(Endometriosis,EMS)是一种雌激素依赖性妇科疾病,并发症主要以痛经、不孕为主。中医药治疗本病具有缓解疼痛、促进怀孕、不良反应少等优势。通过参考近几年文献,从中药促凋亡分子作用机制在子宫内膜异位症中的作用进行综述,发现活血化瘀等中药可能是通过抑制PI3K/Akt/mTOR信号通路、NF-κB通路以及下调Bcl-2,上调Fas、Caspase-3等因子调节凋亡水平,治疗子宫内膜异位症。Endometriosis(EMS)is an estrogen-dependent gynecological disease.The main complications of the disease are dysmenorrhea and infertility.TCM has the advantages of relieving pain and promoting pregnancy with its less adverse reactions in the treatment of EMS.This study reviewed the pro-apoptotic molecular mechanism of Chinese medicinal in treating endometriosis,by referring to the literatures in recent years.It is found that Chinese medicinal,which has the action of promoting blood circulation and removing blood stasis,may inhibit PI3K/Akt/mTOR signaling pathway and NF-kB pathway,down-regulate Bcl-2,up-regulate Fas and Caspase-3 to regulate the level of apoptosis in the treatment of endometriosis.

关 键 词：子宫内膜异位症 中药 凋亡 

分 类 号：R271.9[医药卫生—中西医结合]