盐酸普萘洛尔喷膜剂的含量测定方法研究  

Study on the content determination of propranolol hydrochloride film spraying agent

作　　者：李维超[1] 张囡[1] 左海亮[1] 孙燕燕[1] Li Weichao;Zhang Nan;Zuo Hailiang;Sun Yanyan(Tianjin Children's Hospital,Tianjin 300134)

机构地区：[1]天津市儿童医院,天津300134

出　　处：《天津药学》2020年第4期4-5,共2页Tianjin Pharmacy

摘　　要：目的:建立对盐酸普萘洛尔喷膜剂中盐酸普萘洛尔的定量检测方法。方法:按照《中国药典》2020年版二部项下的相关要求对盐酸普萘洛尔进行含量测定,应用紫外分光光度法法于290 nm处测定盐酸普萘洛尔含量。结果:盐酸普萘洛尔检测质量浓度线性范围为10.1~121.2μg/ml(r=0.9995),平均回收率为100.3%,RSD为0.71%,3批样品含量为99.9%、100.8%和101.6%。结论:定量检测方法准确、可靠、简单、快速。Objective:To establish a quantitative method for the content determination of propranolol hydrochloride in film spraying agent.Method:According to the relevant requirements under the second part of the Chinese Pharmacopoeia 2020 edition,the content of propranolol hydrochloride was determined by ultraviolet spectrophotometry at 290 nm.Results:The linear range of propranolol hydrochloride was 10.1~121.2μg/ml(r=0.9995).The average recovery was 100.3%(RSD was 0.71%).The contents of three batches of samples were 99.9~101.6%.Conclusion:The quantitative determination method is accurate,reliable,rapid,and straightforward.

关 键 词：盐酸普萘洛尔 紫外分光光度法 定量分析 

分 类 号：R927.2[医药卫生—药学]