Association of ACE Gene with Metabolic Syndrome, Hypertension and Alzheimer Disease by RFLP-PCR  

作　　者：Stanislav Alexandra Alina 

机构地区：[1]Department of Genetics,Faculty of Biology,University of Bucharest,1-3 Intr.Portocalelor,060101,Bucharest 6th District,Romania [2]Clinical Laboratory-Bacteriology,Giurgiu County Emergency Hospital,080306,Giurgiu,Romania

出　　处：《Journal of Chemistry and Chemical Engineering》2020年第4期105-112,共8页化学与化工（英文版）

摘　　要：ACE gene is associated with multifactorial diseases:metabolic syndrome,obesity,diabetes mellitus,hypertension,stroke,myocardial infarction,ageing,Alzheimer disease,acute pulmonary failure and COVID-19 infections.The purpose of this study is to test the association between the II,ID and DD polymorphisms of angiotensin-converting enzyme(ACE)gene,and metabolic syndrome,hypertension(HBP)and Alzheimer disease(AD),based on clinical data and biochemical laboratory investigations conducted on inpatients,applying the RFLP-PCR technique.The genotyping of ACE gene was carried out by RFLP-PCR on the basis of DNA isolated from total blood in 144 subjects selected at Giurgiu County Emergency Hospital.The results were statistically processed by the Hardy-Weinberg equilibrium,Odds Ratio,VMD,StatsDirect and PyElph software.The II,ID and DD polymorphisms of ACE gene identified by the RFLP-PCR present a high risk of developing the metabolic syndrome in the MS,hypertension and Alzheimer disease groups.

关 键 词：ACE gene metabolic syndrome HYPERTENSION Alzheimer disease 

分 类 号：R54[医药卫生—心血管疾病]