实炎方治疗轻中度大肠湿热型溃疡性结肠炎的临床观察  

Clinical observation on Shiyan Prescription in treating mild and moderate ulcerative colitis of large intestine damp-heat syndrome

作　　者：张林曦 冯卓 杨巍[1] ZHANG Linxi;FENG Zhuo;YANG Wei(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《上海中医药杂志》2021年第1期43-46,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫计委“十三五”上海市临床重点专科建设项目(shslczdzk04302)。

摘　　要：目的观察实炎方治疗轻中度大肠湿热型溃疡性结肠炎的临床疗效。方法将60例大肠湿热型溃疡性结肠炎患者随机分为治疗组和对照组,每组30例。治疗组予以中药实炎方口服,对照组予以美沙拉嗪肠溶片口服;两组疗程均为3个月,观察临床疗效,比较主要症状量化积分、修正的Baron评分及血清中白介素-1β(IL-1β)、白介素-10(IL-10)水平的变化情况。结果①治疗组、对照组总有效率分别为93.33%、86.67%;组间临床疗效比较,治疗组明显优于对照组(P<0.05)。②治疗前后组内比较,两组主要症状量化积分均下降,差异有统计学意义(P<0.05);组间积分下降差值比较,治疗组明显高于对照组(P<0.05)。③治疗前后组内比较,两组修正的Baron评分均下降(P<0.05);组间评分下降差值比较,治疗组明显高于对照组(P<0.05)。④治疗前后组内比较,两组IL-1β水平均明显降低,IL-10水平均明显升高(P<0.05);组间治疗后比较,治疗组IL-1β水平明显低于对照组,IL-10水平明显高于对照组(P<0.05)。结论相比美沙拉嗪,实炎方能更好地改善溃疡性结肠炎患者的主要临床症状及结肠黏膜病变,降低血清IL-1β水平,提高血清IL-10水平。Objective To observe the clinical effect of Shiyan Prescription on mild and moderate ulcerative colitis(UC)of large intestine damp-heat syndrome.Methods Sixty patients with ulcerative colitis of large intestine damp-heat syndrome were randomly divided into treatment group and control group,with 30 cases in each group.The treatment group was administered Shiyan Prescription orally,while the control group was administered mesalazine enteric coated tablets orally.The course of treatment in both groups was 3 months.The clinical efficacy was observed,and the quantitative score of main symptoms,modified Baron score and the level changes of serum cytokines interleukin-1β(IL-1β)and interleukin-10(IL-10)levels were detected and compared before and after treatment.Results①The total effective rates of the treatment group and the control group were 93.33%and 86.67%respectively.The clinical efficacy of the treatment group was significantly better than that of the control group(P<0.05).②The quantitative scores of main symptoms in the two groups both decreased after treatment,and the difference before and after treatment was statistically significant(P<0.05).The treatment group showed more significant difference of main symptoms quantitative scores than that of the control group(P<0.05).③The modified Baron score in the two groups both decreased after treatment(P<0.05).The treatment group showed more significant difference of modified Baron score than that of the control group(P<0.05).④The expression level of IL-1βdecreased significantly and the expression level of IL-10 increased significantly in both groups after treatment(P<0.05).The treatment group showed lower expression level of IL-1βand higher expression level of IL-10 compared with the condition in the control group after treatment(P<0.05).Conclusion Compared with mesalazine,Shiyan Prescription can better improve the main clinical symptoms and colonic mucosal lesions,reduce the level of serum IL-1βand increase the level of serum IL-10 in patients with ulcera

关 键 词：溃疡性结肠炎 实炎方 美沙拉嗪 大肠湿热证 中药抗炎 结肠黏膜病变 

分 类 号：R259[医药卫生—中西医结合]