Ni(PPh 3)2Cl2催化2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应  

Nickel-catalyzed Suzuki-Miyaura coupling reaction of 2-chloro pyrimidines with aryl boronic acid

作　　者：巩海鹏[1] 肖雯[1] 胡冰[1] 高帆 张祯 GONG Hai-peng;XIAO Wen;HU Bing;GAO Fan;ZHANG Zhen(College of Science,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]甘肃农业大学理学院,甘肃兰州730070

出　　处：《化学研究与应用》2021年第1期115-122,共8页Chemical Research and Application

基　　金：甘肃农业大学学科建设专项资金项目(GAU-XKJS-2018-121)资助。

摘　　要：本文在Ni(PPh 3)2Cl 2催化下顺利实现了不同取代基2-氯嘧啶与芳基硼酸的Suzuki-Miyaura偶联反应。实验表明,取代基的电子效应和空间位阻效应对2-氯嘧啶的反应活性影响较小。该反应产率良好,官能团耐受性好,为2-芳基嘧啶衍生物的合成提供了一类简单有效的方法。The Ni(PPh 3)2Cl 2 catalyzed Suzuki-Miyaura coupling reaction of various 2-chloro pyrimidines with aryl boronic acids was successfully achieved.The experimental results showed that the electronic and steric hindrance effect of substituents had little effect on the reactivity of 2-chloro pyrimidines.This reaction provided a simple and effective way for the synthesis of 2-aryl pyrimidine derivatives because of its excellent yield and functional group tolerance.

关 键 词：SUZUKI偶联 2-氯嘧啶 芳基硼酸 镍催化 

分 类 号：O626.4[理学—有机化学]