纳米晶体技术在肺吸入给药中的研究进展  

Advances in nanocrystals technology in pulmonary inhalation

作　　者：黄桂婷 罗怡婧 帅书苑 喻华平 陈颖翀 岳鹏飞 HUANG Gui-ting;LUO Yi-jing;SHUAI Shu-yuan;YU Hua-ping;CHEN Ying-chong;YUE Pengfei(Key Laboratory of Moderm Preparation of TCM,Ministry of Education,Jiangxi University of Traditionral Chinese Medicine,Jiangxi Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中国医院药学杂志》2020年第23期2490-2495,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81760715);江西省自然科学基金重点项目(编号:20202ACB206011);江西省研究生创新专项资金项目(编号:YC2020-S374)。

摘　　要：肺吸入给药是可实现肺靶向或全身给药的理想给药途径。然而肺部结构特征的复杂性给开发肺吸入制剂研发带来了困难,纳米晶体技术为解决难溶性药物肺部给药提供了一种有效的方法,其粒径小,可克服肺部中存在的生理屏障,提高药物的生物利用度,近年来引起了药物制剂学家的广泛关注。本文围绕肺部给药的屏障及纳米晶体在肺吸入给药的应用展开综述,期望为促进难溶性药物肺部给药提供借鉴。Pulmonary inhalation is an ideal route of administration that can achieve lung-targeted or systemic delivery. However, the complexity of pulmonary structural characteristics brings difficulties to the development of pulmonary inhalation preparations. Nanocrystal technology provides an effective method to solve the pulmonary administration of poorly soluble drugs. Its small particle size can overcome the physiological barrier existing in the lungs and improve the bioavailability of drugs, which has attracted the attention of pharmaceutical formulologists in recent years. This review focuses on the barrier of pulmonary drug delivery and the application of nanocrystals in pulmonary inhalation drug delivery, so as to provide a reference for promoting pulmonary drug delivery of poorly soluble drugs.

关 键 词：药物纳米晶体 肺部 药物传递 纳米晶体技术 

分 类 号：R944[医药卫生—药剂学]