SARS-CoV-2相关神经侵袭性研究进展  

Advances in the study of SARS-CoV-2 related nerve invasiveness

作　　者：刘鸿坤 郑文斌[1] Liu Hongkun;Zheng Wenbin(Department of Radiology,Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,China)

机构地区：[1]汕头大学医学院第二附属医院放射科,汕头515041

出　　处：《中华脑科疾病与康复杂志（电子版）》2020年第3期169-173,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：越来越多的证据表明,严重急性呼吸系统综合征2型冠状病毒(SARS-CoV-2)对人体损害不局限于呼吸道,还可侵入中枢神经系统,诱发神经系统疾病。SARS-CoV-2病毒作为一种新兴的病毒,可能会对神经系统产生短期及长期影响。加之,目前SARS-CoV-2的临床治疗仅限于对症支持治疗以及使用多种抗RNA病毒药物(如法匹拉韦、羟氯喹),尽管专门针对SARS-CoV-2的疫苗和治疗性抗体在测试中,但这种解决方案具有长期性,需要对其安全性进行彻底测试。因此,了解SARS-CoV-2潜在的神经侵袭机制就显得尤为重要,对其防治工作具有重要的指导意义。本文就SARS-CoV-2的病原学、神经侵袭的可能机制以及与神经系统疾病的关系作一综述,旨在为SARS-CoV-2的有效防控治疗提供依据和参考。There is increasing evidence that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can not only damage the respiratory tract,but also invade the central nervous system and induce nervous system diseases.SARS-CoV-2,as an emerging virus,may have both short-term and long-term effects on the nervous system.In addition,the current clinical treatment of SARS-CoV-2 is limited to symptomatic support therapy and the use of a variety of anti-RNA viral drugs(e.g.,farapiravir,hydroxychloroquine).Although vaccines and therapeutic antibodies specifically targeted at SARS-CoV-2 are also being tested,this solution is long-term because they require thorough testing of their safety.Therefore,it is particularly important to understand the potential nerve invasion mechanism of SARS-CoV-2,which has important guiding significance for its prevention and treatment.This article reviews the etiology of SARS-CoV-2,the possible mechanism of nerve invasion,and its relationship with nervous system diseases,in order to provide evidence and reference for the effective prevention and treatment of SARS-CoV-2.

关 键 词：严重急性呼吸系统综合征2型冠状病毒 冠状病毒感染 中枢神经系统 神经学 

分 类 号：R563.1[医药卫生—呼吸系统]