注射用七叶皂苷钠联合聚氨基葡萄糖羧酸钠医用生物胶体液对结直肠癌术后粘连性肠梗阻的预防效果研究  

Research on Preventive Effect of Sodium Aescinate Injection Combined with Sodium Polyglucosamine Carboxylate Medical Biocolloid Fluid on Adhesion Intestinal Obstruction After Colorectal Cancer Surgery

作　　者：刘仕杰[1] 李兴海[1] 李萌 邵建富[1] LIU Shijie;LI Xinghai;LI Meng;SHAO Jianfu(Dept.of General Surgery,Tangshan People’s Hospital,Hebei Tangshan 063000,China)

机构地区：[1]唐山市人民医院普外二科,河北唐山063000

出　　处：《中国医院用药评价与分析》2020年第12期1453-1455,1459,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省医学科学研究重点课题计划项目(No.20181225)。

摘　　要：目的:探讨注射用七叶皂苷钠联合聚氨基葡萄糖羧酸钠医用生物胶体液对结直肠癌术后粘连性肠梗阻(adhesive intestinal obstruction,AIO)的预防效果。方法:对2013年12月至2020年1月唐山市人民医院收治的180例拟行结直肠癌手术的患者进行研究,按随机数字表法分为观察组(90例)和对照组(90例)。两组患者均进行手术,关腹前使用聚氨基葡萄糖羧酸钠医用生物胶体液冲洗腹腔;术后,对照组患者采用常规治疗,观察组患者在对照组的基础上加用注射用七叶皂苷钠治疗。观察两组患者术后AIO发生情况、手术相关症状(首次排气、首次排便和腹胀缓解)改善时间及住院时间,治疗前后炎症因子[降钙素原(PCT)、C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)]水平变化情况。结果:观察组患者治疗后的AIO发生率明显低于对照组[5.56%(5/90)vs.24.44%(22/90)],差异有统计学意义(χ2=12.593,P<0.001)。观察组患者治疗后手术相关症状改善时间、住院时间明显短于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后的炎症因子PCT、CRP和TNF-α水平均较治疗前明显降低,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05)。结论:注射用七叶皂苷钠联合聚氨基葡萄糖羧酸钠医用生物胶体液可有效降低结直肠癌术后AIO的发生率,缩短患者手术相关症状改善时间和住院时间,减轻机体炎症反应,促进恢复。OBJECTIVE:To probe into the preventive effect of sodium aescinate injection combined with sodium polyglucosamine carboxylate medical biocolloid fluid on adhesion intestinal obstruction(AIO)after colorectal cancer surgery.METHODS:Totally 180 patients undergoing colorectal cancer surgery admitted into Tangshan People’s Hospital from Dec.2013 to Jan.2020 were selected and divided into observation group and control group via random number table,with 90 cases in each group.Patients in both groups received surgical treatment,and the abdominal cavity was washed with sodium glucosamine carboxylate medical bio colloid solution before abdominal closure;after operation,the control group was treated with routine treatment,and the observation group was treated with sodium aescinate for injection on the basis of the control group.The incidences of AIO,improvement time of operation related symptoms(first exhaust,first defecation and abdominal distension relief),length of hospital stays after surgery and changes of inflammatory factor[procalcitonin(PCT),C-reactive protein(CRP)and tumor necrosis factorα(TNF-α)]levels of both groups before and after treatment were observed.RESULTS:The incidence of AIO of observation group after treatment was significantly lower than that of the control group[5.56%(5/90)vs.24.44%(22/90)],with statistically significant difference(χ2=12.593,P<0.001).The improvement time of operation related symptoms and length of hospital stays of observation group were significantly shorter than those of the control group,with statistically significant differences(P<0.05).The inflammatory factors of PCT,CRP and TNF-αlevels of both groups after treatment were significantly lower than those of before treatment,and those of the observation group were significantly lower than the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The combination of sodium aescinate injection and sodium polyglucosamine carboxylate medical biocolloid fluid can effectively reduce the incidence of AIO after c

关 键 词：聚氨基葡萄糖羧酸钠医用生物胶体液 注射用七叶皂苷钠 结直肠癌 粘连性肠梗阻 炎症因子 

分 类 号：R969.4[医药卫生—药理学]