家族性房室结内折返性心动过速遗传与分子学研究进展  

Genetic and Molecular Research of Familial Atrioventricular Nodal Reentrant Tachycardia

作　　者：韩天奇 卫延辉 赵钰 任付先 HAN Tianqi;WEI Yanhui;ZHAO Yu;REN Fuxian(Xinxiang Medical University,Xinxiang 453003,Henan,China;Department of Cardiology,Puyang Oilfield General Hospital,Puyang 457001,Henan,China)

机构地区：[1]新乡医学院,河南新乡453003 [2]新乡医学院附属濮阳市油田总医院心内科,河南濮阳457001

出　　处：《心血管病学进展》2020年第12期1306-1309,共4页Advances in Cardiovascular Diseases

摘　　要：房室结内折返性心动过速(AVNRT)是阵发性室上性心动过速中最常见的一种心律失常。家族性聚集、症状早期发作以及无心脏结构的异常提示遗传因素参与了AVNRT的病理生理。随着遗传学研究的进展,基因突变可导致家族性AVNRT被进一步表明,进而有助于理解AVNRT的分子机制及所导致的电生理改变,同时为临床诊疗提供新的思路及方法,现就近年来与AVNRT相关的遗传与分子学研究进展做一综述。Atrioventricular nodal reentrant tachycardia(AVNRT)is the most common arrhythmia in paroxysmal supraventricular tachycardia.Familial aggregation,early onset of symptoms and lack of structural abnormalities suggest that genetic factors are involved in the pathophysiology of AVNRT.With the progress of genetic research,the mechanism of gene mutation leading to some familial AVNRT has been further elucidated,which helps to understand the molecular mechanism and electrophysiological changes of AVNRT and provides new ideas and methods for clinical diagnosis and treatment.This article reviews the progress of genetic and molecular research related to AVNRT in recent years.

关 键 词：房室结内折返性心动过速 基因 遗传 室上性心动过速 

分 类 号：R541.71[医药卫生—心血管疾病]