妊娠糖尿病孕妇不同孕期抗凝蛋白变化研究  

Studies on Anti-coagulation Protein Degeneration in Pregnant Women with Pregnancy Diabetes Mellitus

作　　者：黄锦维[1] 刘长鈺 林莉敏 马建宏[1] 李广华[1] HUANG Jin-wei;LIU Chang-yu;LIN Li-min;MA Jian-hong;LI Guang-hua(Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Guangzhou,510080,China)

机构地区：[1]广东省人民医院(广东省医学科学院),广州510080

出　　处：《血栓与止血学》2021年第2期196-198,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的通过研究抗凝指标蛋白C(PC)、蛋白S(PS)、抗凝血酶(AT)的变化为不同孕期的妊娠糖尿病孕妇血栓前状态风险监测提供证据。方法采取回顾性分析方法,数据来自17年于广东省人民医院进行孕期保健的240例孕妇。其中实验组为确诊为妊娠糖尿病的孕妇120例。对照组为同期的健康孕妇。按照不同孕期进行比较研究妊娠糖尿病与健康妊娠PC、PS、AT的变化及意义。结果(1)在健康妊娠孕妇的抗凝指标处于动态平衡,而妊娠糖尿病孕妇处于异常变化(2)在孕早期妊娠糖尿病PS较健康孕妇有上升趋势。在晚期妊娠糖尿病孕妇PC值较健康孕妇有下降。结论妊娠糖尿病孕妇晚期抗凝指标PS、PC下降,有出现血栓前状态的危险。Objective To provide evidence by studying anticoagulant index protein C(PC),protein S(PS),anticoagulant enzyme(AT changes for pre-thrombosis risk monitoring of pregnant women with gestational diabetes during pregnancy).Methods Retrospective analysis was carried out from 240 pregnant women who had under been in the Guangdong Provincial People’s Hospital for 17 years.The experimental group was 120 pregnant women diagnosed with gestational diabetes.The control group was healthy pregnant women for the same period.The changes and significance of Gestational Diabetes and Healthy Pregnancy PC,PS and AT were compared according to different pregnancy periods.Results(1)Anticoagulant index was in dynamic balance in healthy pregnant women,while pregnant women with gestational diabetes were abnormally changing(2)There was an upward trend in healthier pregnant women with Gestational Diabetes PS in early pregnancy.In pregnant women with advanced gestational diabetes,PC value decreased compared to healthier pregnant women.Conclusion The anticoagulant index PS and PC decreased in pregnant women with gestational diabetes,and there was a risk of pre-thrombosis.

关 键 词：妊娠糖尿病 蛋白C 蛋白S 抗凝血酶 

分 类 号：R714.256[医药卫生—妇产科学]