微波辅助原位生成水溶性Salen-Cu(Ⅱ)配合物催化水中的两步一锅法click反应  

Microwave-assisted Two Step One-Potclick Reactions in Water Catalyzed by Made in Situ Water-Soluble Salen-Cu(Ⅱ) Complex

作　　者：孙斌 王江淋 SUN Bin;WANG Jiang-lin(College of Environment and Resources,Chongqing Technology and Business University,Chongqing 400067,China)

机构地区：[1]重庆工商大学环境与资源学院,重庆400067

出　　处：《分子催化》2020年第6期525-533,I0002,共10页Journal of Molecular Catalysis(China)

基　　金：重庆工商大学重点研究项目(1352002)资助。

摘　　要：我们在文章中报道原位生成的水溶性Salen-Cu(Ⅱ)配合物(N,N’-双(5-磺酸钠-2-羟基-苯甲基)缩-N,N’-二甲基乙二胺合铜)催化常规加热与微波辐射的水中的两步一锅法click反应.在优化反应条件之后,对碘苯及其衍生物、叠氮化钠与苯乙炔及其衍生物的两步一锅法click反应和卤代烷、叠氮化钠与苯乙炔的三组分两步一锅法click反应进行了考察.在所选择的条件下,这两类click反应都能获得很好的收率,与常规加热模式的三组分两步一锅法click反应相比较,微波加热模式的click反应显示出了特别高的反应效率.A water-soluble Salen-Cu(II) complex was made in situ with the mixture of N,N’-bis[(5-sulfonato-2-hydroxy)benzyl]-N,N’-dimethyl-ethane-1,2-diamine and copper perchlorate in water. This complex was used as catalyst for microwave-assisted two step one-potclick reaction in water. Under the optimal reaction condition, the two step one-pot click reaction of iodobenzene and its derivatives, sodium azide, and phenyl acetylene, and the three component click reaction of halohydrocarbon, sodiumazide, and phenyl acetylene were investigated. It was found that under the optimal reaction condition, the yield in both click reaction was from good to excellent. Comparing with the same reaction under conventional heating mode, the microwave-assisted reaction showed high efficiency.

关 键 词：微波辅助 水溶性Salen Cu配合物 催化 CLICK反应 

分 类 号：O621.3[理学—有机化学] O614.8[理学—化学]