T细胞耗竭机制的研究进展  

Research progress in mechanisms of T cell exhaustion

作　　者：刘宁[1] 徐屹[2] 段丁瑜(指导)[2] LIU Ning;XU Yi;DUAN Ding-Yu(State Key Laboratory of Oral Diseases,Department of Periodontology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学,成都610041 [2]四川大学华西口腔医院牙周科,成都610041

出　　处：《中国免疫学杂志》2021年第1期103-108,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81700984)。

摘　　要：在慢性感染性疾病及肿瘤的进展过程中,持续性的抗原刺激会导致T细胞耗竭。耗竭T细胞的效应功能会在疾病进展过程中逐渐出现障碍直至丧失,从而影响机体对疾病的有效控制。T细胞耗竭的机制以及通过逆转耗竭T细胞来治疗慢性感染性疾病和肿瘤已成为近年的研究热点。本文将对耗竭T细胞的主要特点、耗竭现象的逆转及其与疾病之间的关系进行综述。T cell exhaustion displays stepwise and progressive losing of immune functions under conditions of antigen-persistence stimulation,which occurs following chronic infections and tumor progression.And the host always cannot control infections and tumors effectively because of T cell exhaustion.Mechanism of T cell exhaustion as well as the treatment of chronic infectious diseases and tumors by reversing exhausted T cells have become a research hotspot in recent years.This article will review the main features of exhausted T cells,the reversal of T cell exhaustion and the relationship between T cell exhaustion and diseases.

关 键 词：耗竭T细胞 抑制性受体 细胞因子 慢性感染 

分 类 号：R392.12[医药卫生—免疫学]