老年患者抗菌药源性肾损伤分析  

Analysis of antimicrobial drug-induced renal injury in elderly patients

作　　者：段文琪 赵明[2] 杨莉萍[2] DUAN Wenqi;ZHAO Ming;YANG Liping(Department of Pharmacy,Beijing Xiaotangshan Hospital,Beijing 102211;Department of Pharmacy,Beijing Hospital,National Center of Gerontology,Assessment of Clinical Drugs Risk and Individual Application Key Laboratory,Beijing 100730,China)

机构地区：[1]北京市小汤山医院药剂科,102211 [2]北京医院药学部,国家老年医学中心,药物临床风险与个体化应用评价北京市重点实验室,100730

出　　处：《中国老年保健医学》2020年第6期21-24,共4页Chinese Journal of Geriatric Care

摘　　要：抗菌药物广泛用于老年感染患者。老年患者基础疾病多,在使用抗菌药物时需兼顾临床疗效及肾损伤情况。本文通过查阅相关文献,总结归纳抗菌药物引发肾损伤的临床机制及类型,包括间质性肾炎、肾小球损伤、肾小管损伤及结晶性肾脏病理损害,并列举常见抗菌药物诱发肾损伤机制,提出老年患者用药注意事项,旨在提高临床使用抗菌药物警惕,保证用药效率及安全,提高医疗服务水平。Antibacterial drugs are widely used for the treatment of various types of bacterial infections in the elderly patients.It is necessary to focus on the clinical efficacy and kidney damage when using antibacterial drugs.Here we summarize the clinical mechanisms of drug-induced renal injury,we propose four phenotypes of drug-induced renal injury,including nephrolithiasis,glomerular and tubular injury and renal pathological damage.It also lists the mechanisms of common antibacterial drugs which induce kidney injury,and puts forward the precautions for medication in elderly patients.We believe that recognizing drug-induced renal injury and developing strategies to prevent adverse reactions can improve the level of medical services.

关 键 词：抗菌药物 药源性肾损伤 合理用药 

分 类 号：R969.3[医药卫生—药理学]