“颅底七穴”改善帕金森病伴发抑郁临床疗效观察  

Clinical Observation on Treatment of Parkinson’s Disease with Depression by the“Seven Acupoints of Cranial Base”

作　　者：袁盈[1] 蔡向红[2] 陈枫[1] YUAN Ying;CAI Xianghong;CHEN Feng(Wangjing Hospital of Chinese Academy of Chinese Medicine,Beijing 100102;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院望京医院针灸脑病科,100102 [2]北京中医药大学,100029

出　　处：《中国老年保健医学》2020年第6期27-30,共4页Chinese Journal of Geriatric Care

基　　金：首都医学发展基金自主创新项目(项目编号:SF-2009-Ⅲ-08)。

摘　　要：目的观察"颅底七穴"对帕金森病伴发抑郁(PDD)患者汉密尔顿抑郁量表(HAMD)、帕金森病综合评分表Ⅰ(UPDRS-Ⅰ)和贝克抑郁问卷Ⅱ(BDI-Ⅱ)结果的影响。方法研究纳入帕金森病伴发抑郁病例110例,随机分为两组,最终用于数据分析97例,其中治疗组46例,对照组51例。两组患者均延续入组前帕金森病的治疗方案,针对其抑郁症状,治疗组应用"颅底七穴"针刺法,对照组予西药艾司西酞普兰口服。于治疗前、治疗后1月、2月、3月记录患者HAMD(17项版本)、UPDRS-Ⅰ和BDI-Ⅱ评分情况;并于治疗前和治疗3月后检查血常规和心电图作为安全性指标。临床有效率由HAMD结果计算得出,应用SPSS 21.0进行数据分析。结果治疗组总有效率为91.30%,优于对照组的88.24%,组间对比差异不具有统计学意义(P>0.05)。治疗前后两组临床量表评分结果显示,治疗组和对照组HAMD和BDI-Ⅱ评分均有显著降低,但组间差异不具有统计学意义(P>0.05);治疗前后两组UPDRS-Ⅰ评分降幅治疗组明显大于对照组,组间对比差异具有统计学意义(P<0.05)。纳入研究的100例帕金森病伴发抑郁患者中,治疗组不良事件发生率为13.04%,对照组为15.69%。结论"颅底七穴"针法对帕金森病伴发抑郁患者的HAMD、UPDRS-Ⅰ和BDI-Ⅱ评分结果均有不同程度的改善,改善程度不差于口服艾司西酞普兰;且其对全身症状、智力损害和思维障碍等的改善作用尤为显著,优于口服艾司西酞普兰。Objective To observe the effect of the"seven acupoints of cranial base"(SACB)on Hamilton depression scale(HAMD)、Unified Parkinson’s disease rating scale section I(UPDRS-I)and Beck Depression inventory II(BDI-II)in patients suffering Parkinson’s disease with depression(PDD).Methods A total of 100 patients suffering PDD,who met the inclusion criteria,were randomly divided into SACB(treatment)group and medicine(control)group(n=46 to 51 cases at last analysis).On the basis of the original PD treatment,the patients in two groups accept SACB and Escitalopram Oxalate Tablets separately,for 3 months in the same period.Before and after the treatment,all patients were evaluated by HAMD、UPDRS-Ⅰand BDI-Ⅱ.According to the HAMD score,the clinical efficiency was calculated and SPSS 21.0 was used to analyze the data.Results The total effective rate is 91.30%and 88.24%separately,there’s no significant difference between the two groups(P>0.05).After treatment,the scores of HAMD、UPDRS-I and BDI-II all changes a lot,especially in UPDRS-I,the treatment group showed more significant improvement(P<0.05).The incidence rate of adverse event in the two groups is 13.04%and 15.69%separately.Conclusion The SACB has good effect on PDD in improving the scores of HAMD、UPDRS-I and BDI-Ⅱ.It can significantly improve the body’s discomfort and mental level.

关 键 词：颅底七穴 帕金森病伴发抑郁(PDD) 汉密尔顿抑郁量表(HAMD) 临床观察 

分 类 号：R246.6[医药卫生—针灸推拿学]