细胞衰老、端粒、线粒体在慢阻肺中的研究进展  

Cell senescence、telomere、mitochondria in chronic obstructive pulmonary disease:research progress

作　　者：邓瑞冰 钟晓芃[1] 丁钋[1] DENG Ruibing;ZHONG Xiaopeng;DING Po(Emergency Department,Tianjin Union Medical Center,Tianjin 300191,China)

机构地区：[1]天津市人民医院急诊病房,300191

出　　处：《中国老年保健医学》2020年第6期122-125,共4页Chinese Journal of Geriatric Care

摘　　要：慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)是一个全球性的重要健康问题,患病率随着年龄的增长而增加。越来越多的证据表明,与年龄相关的结构和功能改变增加了慢性阻塞性肺疾病的致病易感性。细胞衰老的发生随着年龄的增长而增加,并表现出衰老相关分泌表型(Senescence-associated secretory phenotype,SASP)。与慢性阻塞性肺疾病的发病机制有关。本文主要讨论细胞衰老、端粒、线粒体在慢性阻塞性肺疾病中的研究进展。Chronic obstructive pulmonary disease(COPD)is a major global health problem and increases in prevalence with age.Growing evidences suggest that age-associated structural and functional alterations enhance pathogenetic susceptibility to chronic obstructive pulmonary disease.The incidence of cell senescence increases with advancing age,it is related to the pathogenesis of chronic obstructive pulmonary disease.This review mainly discusses the research progress of cell senescence、telomere and mitochondria in chronic obstructive pulmonary disease.

关 键 词：慢性阻塞性肺疾病 细胞衰老 端粒 衰老相关分泌表型 线粒体 

分 类 号：R563.9[医药卫生—呼吸系统]