萝卜硫素在临床营养干预中的应用研究进展  

Research progress of sulforaphane in clinical nutrition intervention

作　　者：潘宇(综述)[1] 吴伦清(审校)[1] PAN Yu;WU Lun-qing(Department of Nutrition,Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530021,Guangxi,China)

机构地区：[1]广西壮族自治区人民医院营养科,广西南宁530021

出　　处：《肠外与肠内营养》2020年第6期372-375,共4页Parenteral & Enteral Nutrition

摘　　要：萝卜硫素是一种天然的植物活性成分,主要以其前体萝卜硫苷形式广泛存在于西兰花等十字花科蔬菜中。研究发现,萝卜硫素是非常具有潜力的营养干预物质。萝卜硫素可通过靶向激活转录因子Nrf2,进而激活下游大于500个具有细胞保护功能基因的表达,发挥抗氧化、抑制炎症、解毒、抗糖化、免疫调节等多种细胞保护作用。本文综述了萝卜硫素基于营养基因组学的营养干预作用,介绍了萝卜硫素在肿瘤防治、糖尿病干预以及幽门螺杆菌抑制中的应用研究进展。Sulforaphane is a natural plant active ingredient,which is widely present in cruciferous vegetables such as broccoli,mainly in the form of its precursor sulforaphane.Previous study found that sulforaphane was a very potential nutritional intervention substance.Sulforaphane can activate the transcription factor Nrf2,and then activate the expression of more than 500 genes with cell protection function downstream,which play a variety of cell protection functions such as anti-oxidation,anti-inflammation,detoxification,anti-glycation,and immune regulation.This article reviews the effects of sulforaphane on nutrition intervention based on nutritional genomics and introduces the research progress of sulforaphane in cancer prevention,diabetes intervention and Helicobacter pylori inhibition.

关 键 词：萝卜硫素 NRF2 营养基因组学 细胞保护基因 

分 类 号：R459.3[医药卫生—治疗学]