去甲斑蝥素新型制剂研究进展  

Research progress in new formulations of norcantharidin

作　　者：黄思凡 张元声 陈建明[1] 武鑫 HUANG Sifan;ZHANG Yuansheng;CHEN Jianming;WU Xin(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Shanghai Weier Laboratory,Shanghai 201712,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]上海维洱实验室,上海201712

出　　处：《药学实践杂志》2021年第1期1-3,8,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81772749);上海市青年科技启明星计划资助(18QB1400400);上海科技小巨人工程项目(1902HX76600);上海青浦区产学研合作发展资金项目资助(青产学研2019-5)。

摘　　要：目的综述去甲斑蝥素新型制剂研究进展。方法通过查阅近年来有关去甲斑蝥素新型制剂的中外文献,对其研究进展进行归纳总结与分析。结果经过对微球、纳米粒、脂质体和微乳等载药系统包载去甲斑蝥素的情况进行分析,结果表明去甲斑蝥素新型制剂是极具开发潜力的新型制剂。结论去甲斑蝥素是一种优良的抗肿瘤药物,但传统的注射剂和片剂在临床应用上有很大的毒副作用。根据目前研究结果显示,将其制备为新型制剂可以增强靶向性,减小对肾脏和泌尿系统的毒副作用,更好地发挥药效。因此,将去甲斑蝥素制成新型制剂具有良好的发展前景。Objective To review the research progress in new formulations of norcantharidin.Methods The foreign and domestic literature search in the new formulations of norcantharidin was conducted.The research and development of norcantharidin formulations were summarized and commented.Results The drug delivery systems,such as microspheres,nanoparticles,liposomes,and microemulsions,have great development potential as the new formulations for norcantharidin.Conclusion Norcantharidin is an excellent anti-tumor drug.The traditional injections and tablets have serious side effects in clinical application.The new formulations reduced the renal and urinary toxicity and side effects.Those formulations provided better therapeutic effects as target medication.Therefore,the new norcantharidin formulations have great development prospects.

关 键 词：去甲斑蝥素 微球 纳米粒 脂质体 微乳 

分 类 号：R944[医药卫生—药剂学]