红景天苷单体与坤复康片大鼠口服药动学特征的比较  

Comparison of the pharmacokinetic characteristics of pure salidroside and Kunfukang pills after oral administration

作　　者：刘昕竹 徐人杰 冯城[2] 魏昕[1] LIU Xinzhu;XU Renjie;FENG Cheng;WEI Xin(Department of Pharmacy,Xinhua Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China;Department of Clinical Pharmacy,Shaoxing Women and Children’s Hospital,Shaoxing 312000,China)

机构地区：[1]上海交通大学医学院附属新华医院药学部,上海200092 [2]绍兴市妇幼保健院临床药学室,浙江绍兴312000

出　　处：《药学实践杂志》2021年第1期49-52,共4页Journal of Pharmaceutical Practice

基　　金：上海交通大学医学院医院药学科研基金(JDYX2017QW005);上海交通大学医学院附属新华医院院基金(XH2053)。

摘　　要：目的研究红景天苷单体和坤复康片在大鼠体内的药动学特征,探讨药物配伍对红景天苷单体在大鼠体内过程的影响。方法用LC/MS/MS法测定红景天苷和坤复康片在大鼠体内的血药浓度,估算两者的药动学参数。结果红景天苷和坤复康在大鼠体内主要药动学参数AUC0−t分别为(587.11±35.02)和(956.35±47.65)ng·h/ml;cmax分别为(85.81±15.66)和(143.86±46.91)ng/ml,两者有显著差异。结论坤复康片中的其他成分会影响红景天苷的吸收、分布和排泄。Objective To study the pharmacokinetic differences of pure salidroside and Kunfukang pills in rats and explore the pharmacokinetic changes of salidroside as a pure form or in the mixture.Methods The rats were divided into two groups.One group received pure salidroside and the other was administrated with kunfukang pills.Concentrations of salidroside in both groups were determined by LC/MS/MS method.The main pharmacokinetic parameters were calculated.Results AUC0−t of salidroside was(587.11±35.02)in pure salidroside group and(956.35±47.65)ng·h/ml in Kunfukang group.cmax was(85.81±15.66)and(143.86±46.91)ng/ml separately,with significant difference.Conclusion The results indicated that other components in kunfukang pills had influence on the absorption,distribution and elimination of salidroside.

关 键 词：坤复康 红景天苷 口服 药动学 

分 类 号：R969.1[医药卫生—药理学]