奥卡西平与奥氮平及哌罗匹隆联用致药物超敏反应综合征1例分析  

One case of Hypersensitivity Syndrome Induced by Oxcarbazepine Combined with Olanzapine and Piropilone

作　　者：李焕芬[1] 王金宝[1] 王来海[1] 张瑞岭[1] LI Huanfen;WANG Jinbao;WANG Laihai;ZHANG Ruiling(Department of Pharmacy,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang Henan 453002,China)

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《中国药物警戒》2021年第1期84-86,共3页Chinese Journal of Pharmacovigilance

基　　金：河南省卫生科技创新型人才工程专项(2011-2015)(第3052号)。

摘　　要：目的分析奥卡西平与奥氮平及哌罗匹隆联用导致药物超敏反应综合征,为临床早期发现和识别提供参考。方法通过对1例精神分裂症患者使用奥卡西平、奥氮平和哌罗匹隆后出现发热、全身皮肤发红伴皮疹及血液系统异常的病例报道,结合国内外文献进行分析。结果和结论奥卡西平很可能是引起药物超敏反应综合征的致敏药物,但由于用药前基因检测仍不普及,所以对药物超敏反应综合征的早期识别和及时停药处理是减少严重不良反应的关键。Objective To analyze the drug-induced hypersensitivity syndrome(DISH)caused by the combination of oxcarbazepine,olanzapine and piropilon.Methods The clinical data about one patient with schizophrenia who developed fever,redness of the skin with rash and abnormalities of the blood system caused by olanzapine,oxcarbine and piropilon was analyzed based on related literature at home and abroad.Results and Conclusion Oxcarbazepine is probably an allergenic drug that causes DISH.However,genetic testing before drug administration is still not easily accessible,so early identification of DISH and quick drug discontinuation are the keys to reducing severe adverse reactions.

关 键 词：奥卡西平 奥氮平 哌罗匹隆 药物超敏反应综合征 

分 类 号：R994.11[医药卫生—毒理学]