1例原发性血小板减少症合并肺血栓栓塞患者出现药物性肝损伤药学监护  

Pharmaceutical Care for Drug-induced Liver Injury in a Patient with Idiopathic Thrombocytopenic Purpura Complicated with Pulmonary Thromboembolism

作　　者：王应楷 崔向丽 刘丽宏[1] WANG Yingkai;CUI Xiangli;LIU Lihong(Department of Pharmacy,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China;Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京朝阳医院药事部,北京100020 [2]首都医科大学附属北京友谊医院药学部,北京100050

出　　处：《中国药物警戒》2021年第1期90-93,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的通过临床药师参与1例原发性血小板减少症、肺血栓栓塞、药物性肝损伤患者的治疗过程,讨论药学监护的重要性。方法临床药师协助医师对1例原发性血小板减少合并肺血栓栓塞患者进行抗凝药物的选择、剂量调整、保肝药物的选择,寻找可能导致肝损伤的药物,协助医师优化个体化治疗方案。结果患者经过治疗后,肝功能基本正常,抗凝安全有效。结论临床药师参与临床治疗中的药学监护,提高了治疗有效性,保障了患者的用药安全。Objective To study the importance of pharmaceutical care through a clinical pharmacist involved in the treatment of a patient with idiopathic thrombocytopenic purpura,pulmonary thromboembolism,and druginduced liver injury.Methods A clinical pharmacist assisted the physician in selecting an anticoagulant and its dose,adjusting the hepatoprotective drug,and identifying the drug that might have caused liver damage in a patient with primary thrombocytopenia and pulmonary thromboembolism so that the physician was able to make an individualized treatment plan.Results After treatment,the patient’s liver functions basically returned to normal,and the anticoagulation medication was safe and effective.Conclusion Clinical pharmacists’participation in pharmaceutical care can improve the efficacy of medication and ensure the safety of patients.

关 键 词：原发性血小板减少 肺血栓栓塞 药物性肝损伤 药学监护 

分 类 号：R969.3[医药卫生—药理学]