血清中肌钙蛋白Ⅰ、白介素-6、肿瘤坏死因子-α在老年冠心病患者中的表达水平及意义  

The expression level and significance of serum troponin Ⅰ, interleukin-6 and tumor necrosis factor alpha in elderly patients with coronary heart disease

作　　者：李广明 王兆赟 娄宇 李颖[4] LI Guangming;WANG Zhaofu;LOU Yu;LI Ying(Department of Cardiovascular Medicine,Shahekou District Hospital,Dalian,Liaoning,116021,China;Department of General Medicine,Shahekou District Hospital,Dalian,Liaoning,116021,China;Department of Cardiology,the Second Affiliated Hospital of Dalian Medical University,Dalian,Liaoning,116023,China;Department of GeneralWard,Dalian Central Hospital,Dalian,Liaoning,116033,China)

机构地区：[1]大连市沙河口区医院心血管内科,辽宁大连116021 [2]大连市沙河口区医院综合内科,辽宁大连116021 [3]大连医科大学附属第二医院心内科,辽宁大连116023 [4]大连市中心医院全科病房,辽宁大连116033

出　　处：《当代医学》2021年第3期101-103,共3页Contemporary Medicine

摘　　要：目的探讨血清中肌钙蛋白I(cTnI)、细胞白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在老年冠心病患者中的表达水平及临床意义。方法选取2018年1月至2019年10月本院收治的150例冠心病患者为观察组,包括急性心肌梗死(AMI)78例,稳定性心绞痛(SAP)40例,不稳定性心绞痛(UAP)32例;心功能分级Ⅰ级34例,Ⅱ级76例,Ⅲ级40例;另选取同期健康体检志愿者50名为对照组。比较观察组与对照组、观察组中不同疾病类型及不同心功能分级患者血清cTnI、IL-6、TNF-α水平。结果观察组血清cTnI、IL-6、TNF-α水平均高于对照组(P<0.05);AMI组血清cTnI、IL-6、TNF-α水平均高于UAP组及SAP组(P<0.05);UAP组血清cTnI、IL-6、TNF-α水平均高于SAP组(P<0.05);心功能分级Ⅲ级血清cTnI、IL-6、TNF-α水平高于Ⅱ级及Ⅰ级患者(P<0.05);心功能分级Ⅱ级血清cTnI、IL-6、TNF-α水平均明显高于Ⅰ级患者(P<0.05)。结论老年冠心病患者血清c TnI、IL-6、TNF-α均明显高于正常人群,且不同冠心病病理类型及不同心功能分级患者间cTnI、IL-6、TNF-α表达存在明显差异。因此,通过早期检测cTnI、IL-6、TNF-α水平,可为冠心病的诊断、病情评估及临床治疗提供指导依据。Objective To investigate the expression level and clinical significance of serum cTnI, IL-6, TNF-α in elderly patients with coronary heart disease. Methods 150 patients with coronary heart disease admitted to our hospital from January 2018 to October 2019 were selected as the observation group, including 78 patients with acute myocardial infarction(AMI), 40 patients with stable angina pectoris(SAP), 32 patients with unstable angina pectoris(UAP), 34 patients with cardiac function grade Ⅰ, 76 patients with grade Ⅱ, 40 patients with grade Ⅲ, another 50 healthy volunteers at the same period were selected as the control group. The serum levels of cTnI, IL-6 and TNF-α were compared between the two groups.Results The levels of serum cTnI, IL-6, TNF-α in the observation group were higher than those in the control group(P<0.05). The levels of serum cTnI, IL-6, TNF-α in the AMI group were higher than those in the UAP group and the SAP group(P<0.05). The levels of serum cTnI, IL-6, TNF-αin the UAP group were higher than those in the SAP group;the levels of serum cTnI, IL-6, TNF-α in the cardiac function class Ⅲ were higher than those in the class Ⅱ and class Ⅰ patients(P<0.05). The levels of serum c TnI, IL-6, TNF-α in the cardiac function class Ⅱ were significantly higher than that of class I patients(P<0.05). Conclusion Serum cTnI, IL-6 and TNF-α levels in elderly patients with coronary heart disease are significantly higher than those in normal people, and there are significant differences in the expression of c TnI, IL-6 and TNF-α among patients with different coronary heart disease pathological types and different grades of function. Therefore, early detection of cTnI, IL-6, TNF-α levels can provide some guidance for the diagnosis, disease assessment and clinical treatment of coronary heart disease.

关 键 词：老年 冠心病 肌钙蛋白Ⅰ 细胞白介素-6 肿瘤坏死因子-Α 

分 类 号：R541.4[医药卫生—心血管疾病]