新一代测序技术在抗癌药物精准治疗中的研究现状  

Application of New Generation Sequencing Technology in Precision Medicine for Cancer Treatment

作　　者：陈永孜 杨丽雯 李强[2] 陈骏 王冬园 陈秋月 王卓智 李居怡[4] 邓艾平[4] 韩勇[2] 吕永宁[2] 张玉[2] CHEN Yongzi;YANG Liwen;LI Qiang;CHEN Jun;WANG Dongyuan;CHEN Qiuyue;WANG Zhuozhi;LI Juyi;DENG Aiping;HAN Yong;LYU Yongning;ZHANG Yu(Department of Cancer Cell Biology,Cancer Hospital,Tianjin Medical University Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer National Clinical Research Center for Cancer,Tianjin 300060,China;Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province Clinical Research Center for Precision Medicine for Critical Diseases,Wuhan 430022,China;School of Biomedical Engineering,Tianjin Medical University,Tianjin 300070,China;The Central Hospital of Wuhan City,Wuhan 430024,China)

机构地区：[1]天津医科大学肿瘤医院肿瘤细胞生物学实验室,天津市肿瘤防治重点实验室,国家肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津300060 [2]华中科技大学同济医学院附属协和医院药学部,湖北省重大疾病精准用药医学研究中心,武汉430022 [3]天津医科大学生物医学工程与技术学院,天津300070 [4]武汉市中心医院,武汉430024

出　　处：《医药导报》2021年第2期193-198,共6页Herald of Medicine

基　　金：国家自然科学基金资助项目(81673456);武汉市卫健委重大项目(WX18M02)。

摘　　要：新一代测序技术的迅猛发展为个性化医学提供前所未有的潜力,生物医学和癌症基因组学在大数据时代也随之发生巨大的变革。随着生物科学技术和计算机处理数据能力的不断提高,高通量测序在多组学生物数据的获取和挖掘中发挥了关键作用。如今,它已经成为了生物学家进行科学研究不可或缺的工具,并在抗癌药物精准治疗领域做出了重要贡献。该文将针对不同测序方法在抗癌药物精准治疗中的作用进行阐述,探讨新一代测序技术在其中的指导意义。The rapid progress of new generation sequencing technology has provided great potential for personalized medicine.Biomedicine and cancer genomics have also undergone great changes in the era of big data.With the continuous improvement of biological science and technology and the ability of computer processing data,high-throughput sequencing plays a key role in the acquisition and mining of multi-omics biological data.Currently,it has become an important tool for biologists to conduct scientific research and has made valuable contributions to the field of anticancer drug discovery.This review will focus on the application of different sequencing methods in drug discovery,and provides beneficial suggestions for new generation sequencing techniques in it.

关 键 词：精准医疗 抗癌药物 新一代测序技术 癌症 

分 类 号：R979.1[医药卫生—药品]