长期应用质子泵抑制药与胃癌的关联性研究进展  

Research Progress on the Relationship Long-term Use of Proton-Pump Inhibitors and Gastric Cancer

作　　者：伊春芳 YI Chunfang(Department of Pharmacy,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学附属医院药学部,沈阳110032

出　　处：《医药导报》2021年第2期228-232,共5页Herald of Medicine

摘　　要：质子泵抑制药(PPI)是目前治疗酸相关性疾病的首选药物。近年来,越来越多研究发现长期应用PPI可能与胃黏膜病变相关,甚至导致胃癌的发生。该文通过检索国内外文献,对PPI的药理作用、致癌机制及相关临床研究进行阐述。旨在为临床合理选择和使用PPI,识别胃癌的高危人群,减少PPI相关性胃癌的发生提供参考。Proton pump inhibitors(PPI)are the first choice for the treatment of acid-related diseases currently.However,in recent years,more and more studies have found that long-term use of PPI may be associated with gastric mucosal lesions,which even lead to the occurrence of gastric cancer.This article describes the pharmacological effects,carcinogenic mechanisms,and related clinical research results of PPI by investigating domestic and international literatures.This paper is to provide a reference for the rational selection and use of PPI,to identify high-risk groups of gastric cancer,and to reduce the incidences of PPI-related gastric cancer.

关 键 词：质子泵抑制药 胃癌 幽门螺杆菌 

分 类 号：R975.2[医药卫生—药品]