Comparison of Clinical Characteristics and Outcomes of Pediatric and Adult Patients with Coronavirus Disease 2019 in Shenzhen,China  

作　　者：WANG Fang LAI Chang Xiang HUANG Peng Yu LIU Jia Ming WANG Xian Feng TANG Qi Yuan ZHOU Xuan XIAN Wen Jie CHEN Rui Kun LI Xuan LI Zhi Yu LIAO Li Qun HE Qing LIU Lei 

机构地区：[1]National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Department of Hepatology,Second Hospital Affiliated to Southern University of Science and Technology,Shenzhen 518112,Guangdong,China [2]Fujian Provincial Reproductive Medicine Center,Fujian Maternity and Children's Hospital Affiliated to Fujian Medical University,Fuzhou 350001,Fujian,China [3]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Hepatopancreatobiliary Surgery I,Peking University Cancer Hospital&Institute,Beijing 100142,China

出　　处：《Biomedical and Environmental Sciences》2020年第12期906-915,共10页生物医学与环境科学（英文版）

基　　金：supported by the National Clinical Research Center for Infectious Diseases;Funds for the Construction of Key Medical Disciplines in Shenzhen and the Sanming Project of Medicine in Shenzhen[SZSM201612014]。

摘　　要：Objective Here we aimed to investigate the difference in clinical characteristics and outcomes between pediatric and adult patients with COVID-19.Methods A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treated in the departments of Internal medicine of Shenzhen Third People’s Hospital from January 11 th to February 10 th,2020 were included.The data were obtained from electronic medical records.The epidemiological data,clinical characteristics,length of hospital stays,and outcomes of pediatric and adult patients were compared.Results Compared with adult patients,pediatric patients had a shorter time of symptom onset to hospitalization than adults[median time,1(IQR,1.0-1.0)d vs.3(IQR,2.0-6.0)d,P<0.001],milder or fewer symptoms,less severe chest CT findings.The clinical severity classification of children was less severe than adults.Up to 15 th March,the end of the follow-up,33(100%)children and 292(97.3%)adult patients had been discharged from hospital.Only 2(0.7%)adult patients died,with an overall case mortality of 0.6%.The median length of hospital stay of pediatric patients was shorter than that of adult patients[19(95%CI:16.6-21.4)d vs.21(95%CI:19.9-22.1)d,P=0.024].Conclusion Pediatric patients with COVID-19 had milder or less clinical symptoms,less evident pulmonary imaging changes,better prognosis,and shorter length of hospital stay.

关 键 词：Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Clinical characteristics Pediatric patients 

分 类 号：R563.1[医药卫生—呼吸系统] R725.6[医药卫生—内科学]