参榆洗剂联合曲安奈德益康唑乳膏治疗足癣的疗效观察  

Clinical Observation on Erosive Interdigital Tinea Pedis Treated by Shenyu Solution Combined with Triamcinolone Acetonide and Econazole Nitrate Cream

作　　者：孔韵莹 伍紫炫 朱铭华[2] KONG Yun-Ying;WU Zi-Xuan;ZHU Ming-Hua(Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;Guangdong Second Hospital of Traditional Chinese Medicine,Guangzhou 510095 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省第二中医院,广东广州510095

出　　处：《广州中医药大学学报》2021年第1期52-57,共6页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察参榆洗剂联合曲安奈德益康唑乳膏治疗浸渍糜烂型足癣的临床疗效。【方法】将64例浸渍糜烂型足癣患者随机分为治疗组和对照组,每组各32例。对照组给予曲安奈德益康唑乳膏外涂治疗,治疗组给予参榆洗剂浸泡联合曲安奈德益康唑乳膏外涂治疗,疗程为4周,并于疗程结束后4周进行随访。观察2组患者治疗前后临床症状总积分的变化情况,比较2组患者的病原清除情况和复发情况,评价2组患者的临床疗效和安全性。【结果】(1)治疗过程中,对照组脱落2例,治疗组无脱落病例,最终对照组30例、治疗组32例完成试验。(2)治疗4周后,治疗组的愈显率和总有效率分别为78.1%(25/32)和96.9%(31/32),对照组分别为56.7%(17/30)和90.0%(27/30);2组患者的总有效率比较,差异无统计学意义(P>0.05),但治疗组的愈显率和总体疗效均优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的临床症状总积分均较治疗前明显降低(P<0.05),且治疗组的降低作用明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,治疗组和对照组的病原清除率分别为90.6%(29/32)、86.7%(26/30),组间比较,差异无统计学意义(P>0.05)。(5)在疗程结束后4周,治疗组的复发率为9.4%(3/32),对照组为16.7%(5/30),组间比较,差异无统计学意义(P>0.05)。(6)治疗过程中,2组患者均无明显的不良事件发生。【结论】参榆洗剂联合曲安奈德益康唑乳膏治疗浸渍糜烂型足癣疗效确切,其疗效优于单纯使用曲安奈德益康唑乳膏治疗。Objective To investigate the clinical efficacy of Shenyu Solution combined with Triamcinolone Acetonide and Econazole Nitrate Cream for the treatment of erosive interdigital tinea pedis. Methods Sixty-four patients diagnosed as erosive interdigital tinea pedis were randomly divided into treatment group and control group,and each group had 32 cases. The control group was given external application of Triamcinolone Acetonide and Econazole Nitrate Cream,while the treatment group was given soaking the affected feet with Shenyu Solution together with external application of Triamcinolone Acetonide and Econazole Nitrate. The treatment for the two groups lasted 4 weeks. The follow-up was carried out 4 weeks after the completion of treatment. Before and after treatment, the scores of clinical symptoms in the two groups were observed. The pathogen clearance and the recurrence as well as the clinical efficacy and safety in the two groups were compared. Results(1)During the treatment, 2 cases from the control group dropped out while none case from the treatment group dropped out.And at the end of the trial,30 cases of the control group and 32 cases of the treatment group completed the trial.(2)After treatment for 4 weeks,the markedly effective and curative rate and the total effective rate of the treatment group were 78.1%(25/32)and 96.9%(31/32)respectively,and were 56.7%(17/30)and 90.0%(27/30)in the control group respectively. The intergroup comparison showed that the difference of the total effective rate between the two groups was not statistically significant(P>0.05),but the markedly effective and curative rate and the overall efficacy in the treatment group were superior to those in the control group,the difference being statistically significant(P < 0.05).(3)After treatment, the total scores of clinical symptoms in the two groups were markedly decreased in comparison with those before treatment(P<0.05), and the decrease of the total scores in the treatment group was superior to that in the control group,the difference

关 键 词：中药外治法 参榆洗剂 曲安奈德益康唑乳膏 浸渍糜烂型足癣 

分 类 号：R275.9[医药卫生—中西医结合] R756.3[医药卫生—中医皮科]